舒乐安定(Surazepine)是一种新型的安定剂

属于苯骈二氮杂(艹卓)类(benzodiazepine)的衍生物

具有较强的镇静、安眠抗惊

抗焦虑作用。在国外作为手术前夜的睡眠药应用于临床

取得了较好的效果。在国内由北京医学院药学系和湖北制药厂试制成功

由湖北药厂提供使用。我们于1981年1月将本剂作为针麻木前用药应用于临床

以期提高针麻效果

并进行了脑电观察和测痛试验

以观察其镇静作用及其对皮肤痛阈Surazepine

one of the benzodiazepines

is a new weak sedative providing effects of sadationsleep

anticonvulsion and anxiolytic action. It was used as premedication under careful observation during acupuncture anesthesia and tried in normal persons. The presence of wave and 25-28 times/second waves in EEG was noticed after administration of this drug. The effect varies with the dosage and individual. It can strengthen analgesic effect of acupuncture anesthesia especially together with Fentanyl. Surazepine was used in one hundred and forty patients as premedication with 2mg

3mg

or 4mg one hour preoperatively with satisfactory effect in 85%. The side effect are nausea

vomiting and weakness ( 10.7%) but all were not severe and disappeared spontaneously. For sedation 3mg seems better. Surazepine can reduce nervousness and fear. Patient's BP and pulse rate were stable and analgesic effect of acupuncture anesthesia was improved. It is a good drug for premedication under acupuncture anesthesia.