文献报道调节疼痛和血压的中枢之间有重叠

人和动物高血压情况下发生痛觉减退

中枢内参与痛和镇痛调制的递质系统如内源性鸦片样物质(endogenousOpiate-like Substance

OLS)

5-羟色胺(5-HT)

去甲肾上腺素(NA)等系统又都调节血压;因此

本工作检验;(1)具有镇痛作用的电针刺激对血压有何效应

(2)电针调制疼痛和血压的机理Our experiments showed that analgesic electroacupuncture (EA8/sec

0.5 msec

3V) had a pressor effect

and could increase the unit discharge of locus coeruleus (LC) and nucleus raphe magnus (NRM

both in contolling blood Pressure and pain) in conscious paralysed male rats. But the follow- ing further studies suggested that each of these two nuclei might have pla- yed a predominant role in regulating either pain or blood pressure. (1) The pressor effect of EA was similar to that of LC stimulation. This effect of EA and the excitatory response of LC to EA were not bloc- ked by naloxone. These results were likely to show that the EA pressor effect might be brought about through exciting LC neuron s and that endo- genous opiate-llke substance (OLS) might not be involved in this effect. (2) On the other hand

NRM stimulation had no significant influence on blood pressure

and the excitatory effect of EA on NRM neurons could be completely blocked by naloxone

which was consistent with the fact re- ported by others that EA analgesia could be blocked by naloxone. There- fore

it is possible that NRM does not play an important role in EA press- or effect

but plays a critical role in EA analgesla

which is mediated by OLS.