它可能是参与中枢镇痛的组成部分。我们已在In some previous studies we verified that the factor of moving plays a role in acupuncture analgesia. This study further examines the effect of wrist exercises on event-related potential and subjective pain report. Methods: The present expriments were performed on 20 normal adult subjects and patients with intact sensation. Painful stimuli were applied to a middle nerve of one side forelimb and the cerebral evoked potentials we- re recorded contralaterly and subjective pain reports were recorded. The subject exercised his contralateral wrist 2 to 4 times per second. The execise can produce significant analgesic rating. The effects was statistically significant (P<0.01). The amplitudes of the cerebral evoked potentials with latency 160-260ms component with close relation to pain si- gnificantly decreased. It was statistically significant (P<0.05). These results seem to indicate that moving wrist can inhibit the painful sense and factor of moving plays a role in analgesia. It is a partial physi- ological foundation of acupuncture analgesia.