5--HYDROXYTRYPTAMINE IS AN IMPORTANT MEDIATOR FOR BOTH HIGH AND LOW FREQUENCY ELECTROACUPUNCTURE ANALGESIA
|更新时间:2023-08-11
|
5--HYDROXYTRYPTAMINE IS AN IMPORTANT MEDIATOR FOR BOTH HIGH AND LOW FREQUENCY ELECTROACUPUNCTURE ANALGESIA
Acupuncture ResearchIssue 3, Pages: 212-215(1985)
作者机构:
1. 山东医学院生理教研室
2. 北京医学院生理教研室
作者简介:
基金信息:
DOI:
CLC:
Published:1985
稿件说明:
移动端阅览
5--HYDROXYTRYPTAMINE IS AN IMPORTANT MEDIATOR FOR BOTH HIGH AND LOW FREQUENCY ELECTROACUPUNCTURE ANALGESIA[J]. Acupuncture research, 1985, (3): 212-215.
DOI:
5--HYDROXYTRYPTAMINE IS AN IMPORTANT MEDIATOR FOR BOTH HIGH AND LOW FREQUENCY ELECTROACUPUNCTURE ANALGESIA[J]. Acupuncture research, 1985, (3): 212-215.DOI:
5--HYDROXYTRYPTAMINE IS AN IMPORTANT MEDIATOR FOR BOTH HIGH AND LOW FREQUENCY ELECTROACUPUNCTURE ANALGESIA
Evidences obtained from different lines have shown that 5-hydroxytry- ptamine (5-HT) plays an important role in mediating electroacpuncture ana- lgesia (EAA). However
Cheng and Pomeranz in 1979 reported that p-chlo- rophenylalanine(pCPA)
the specific inhibitor of the 5-HT synthetic enzy me
was effective in decreasing only high frequency EAA
but not the low frequency EAA in the mice. To evaluate whether this is true in the rat
we have used EA of 4 frequencies (2
15
100Hz fixed frequency and 2-15 Hz changing frequenecy EA stimulations) and 2 intensities (3V
9V) to assess the effect of pCPA on EAA. The effect of EAA in control rats injected with normal saline were rather stable in a period of 2 weeks. Intraperitoneal injection of pCPA 320mg/kg) resulted in a marked decrease (-84% to-90%) of the effect of EAA 3 and 5 days after the ip injection
followed by a gradual recovery which completed in 13 days. The decrease of EAA was of similar degree whether low or high frequency
weak or strong intensity EA stimulations were used. It is thus concluded that 5-HT is important in mediating not only high frequency