我室曾观察到针麻下胃大部切除的病人

在针麻效果好时

血浆中游离的5-HT偏低、血小板向血浆内释放5-HT较少和病人的交感神经处于相对抑制或稳定状态。后又在针麻胃大部切除的实验模型上测定狗全血5-HT的含量具有类似现象。同时还观察到胃粘膜APUC细胞内的5-HT和交感神经末稍荧光强度在针麻效果好时均较强

并且两者在分布上存在紧密关系。以上结果提示

针刺调整交感神经以保证针麻手术顺利进行的内在机理之一可能与调节APUD细胞5-HT的储存Fluorohistochemical changes of 5-HT in the APUD cells of mucosal membrane of pyloric antrum after injecting 6-OHDA intraperitoneally and their relationship with acupuncture were investigated in rats by the combi- nation of glyoxylic-acid fluorescence method with physiological and bioc- hemical methods. The fluorescence of sympathetic nervous endings in the ti- ssues of gastrointestinal walls

adrenal glands

vagal nervous trunks

ctc.

were almost disappeared 5 days after a single injection of 6-OHDA intrape- ritoneally

while the fluorescent intensity of 5-HT in the APUD cells was increased compared with that of 5-HT in the APUD cells of control ani- mals. In 6-OHDA plus electroacupuncture group especially in 100mg/kg 6- OHDA plus electroacupuncture group the fluorescent intensity of 5-HT in the APUD cells was increased much more than that in only giving 6-OH- DA group. The present results indicate that sympathetic nerve might participates in the regulation of the storage and release of t-HT in the APUD cells of the mucosal membrane of gastrointestinal tracts and the existence of syne- rgistic action of acupuncture and 6-OHDA on the storage and release of 5- HT in these cells. It is assumed that the regulation of sympathetic nerve on the APUD cells might be one of its peripheral active ways affecting acupuncture analgesia.