我们曾经报道过

在临床针麻胃大部切除术过程中

血中游离5-HT的含量改变与针麻手术效果密切相关。针麻效果好的病人

大多数血浆中游离5-HT的含量明显下降

交感神经的活动处于相对稳定状态。在狗针麻胃大部切除术动物模型中

观察到针麻效果优级的

术中全血5-TH的升高率(与针前血中5-HT的含量比)也比针麻效果差的为低(P<0.05)

在同一模型上

用组织荧光化学的方法观察到

针麻效When the electroacupuncture was given with the 6-OHDA(30mg/kg or 100mg/kg)the contents of 5-HT and 5-HIAA in the whole blood was sign- ificantly decreased as compared with those in saline control groups (P< 0.05)

Moreover

acupuncture analgesia was reinforee by 6-OHDA

while in 6-OHDA or acupuncture groups

they had only a tendency to deerease. The results suggest that there is a cooperative action on the regulatory mechanism of storage and release of 5-HT and acupuncture analgesia be- tween electroacupuncture and 6-OHDA. A possibility of peripheral mechanism of acupuncture analgesia is di- scussed in this paper.