Experiments were done With cats. The results showed that the nocice- ptive discharges of most neurons of nucleus Centralis Lateralis (CL) were attenuated when Somatosensory area II(S II) was stimulated. The same results were also found on the neurons after electroacupuncture at points. The result which is similar to what we have seen at Nucleus Centrum Medi- anum and Nucleus Parafesicular suggests that the descending regulation of S II on nucleus of intralamina is one way of central nervous system invo- lved in the inter-regulation of pain and analgesia.