针刺对痛情绪反应的抑制效应与边缘系统

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电针和刺激背中缝核(NDR)、蓝斑核(LC)皆可明显抑制海马锥体细胞层单位自发放电

损毁 LC 后针刺压抑海马放电Role of n.dorsal raphe(NDR)and the serotoninergic receptor anta- gonist-cyproheptadine on electroacupuncture(EA)regulating the spontan- eous discharges of units in the dorsal hippocampal pyramidal layer at the CA_2 and CA_3 regions was studied in rats anesthetized with urethane.The spontaneous activities were mostly inhibited by EA at aeupoint“Jiaji” or“Zusanli”. After NDR lesion or intravenous injection cyproheptadine the freque- ncy of hippocampal spontaneous activity in some cells was increased and the pattern of firing in some cells was changed.The spontaneous discha- rge of hippocampal cells mainly turned by to be enhanced the EA. This result suggests that the NDR and serotonin may play a role in the pathway mediating the EA effect on hippocampal cell activity.