尾核是锥体外系中与针刺镇痛有密切关系的一个结构

刺激尾核可产生镇痛作用

损毁尾核头部可减弱针刺镇痛

电刺激“合谷”时可在尾核记录到诱发电位

刺激人脑尾核头部能缓解晚期肿瘤病人的恶痛。本室曾证实

MRF是38 rabbits were anesthetized with chloralose and urethane. As soon as the animal recovered its consciousness it was immobilized with flaxedil and artificial respiration. The electrical activities of the nociceptive neurons were recorded by glass microelectrodes (tip 1-3μm) in the ranges P7-11 R2-3 HO

+

1-6

with the aid of a stereotaxic apparatus. 116 of the nociceptive units responded to noxious stimuli which applied to the peroneal nerve with a short train of pulses. Among them

64 units (55%)responded by an increase in frequency of the discharge to noxious stimuli (pain-excition neuron

PEN). In contrast

there were 52 units (45%)

which responded to noxious stimuli quite differently

by having a decrease in the frequency of the discharge (pain-inhibition neuron

PIN). Similar results were obtaingd by the stimulation of the head of caudate nucleus with the same train of pulses: an ex-citatory effect was observed in PEN. and an inhibitory effect in PIN. However

after electroacupuncture by penetrating acupoint "Hegu" or dolantin given intra-ven ously

under the same conditions used above. We again stimulated both the head of caudate nucleus

eliciting an inhibitory effect on PEN. And a reduction of inhibition or release from it on PIN. From the results presented

it indicated that head of caudate nucleus was connected with the modultion of the nociceptive neuronal activity in M. R. F. and was related to the effect of acupuncture. The effect of atropine on the head of caudate nucleus stimulation. The in-hibitory effect of the head of caudate nucleus on the nociceptive nucleus on thenociceptive discharges was diminished or cancelled by injection of atropine (0.3-0.5mg/kg i. v.). This suggested that the cholinergic system in the caudate nucleus was also involved in the pain impulses in M. R. F.