EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS

Wang Youjing Wang Shuangkun

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EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS

更新时间：2023-08-11

- EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS
- Acupuncture Research Issue 3, Pages: 348-351(1989)
- 作者机构：
  
  中国中医研究院针灸研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1989
- 稿件说明：
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Wang Youjing Wang Shuangkun. EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS[J]. Acupuncture research, 1989, (3): 348-351.
DOI：

Wang Youjing Wang Shuangkun. EFFECTS OF INTRAPERITONEAL INJECTION OF NALOXONE ON THE ANALGESIC EFFECT AND THE CHANGES OF BRAIN CATECHOLAMINE CONTENTS INDUCED BY ELECTROACUPUNCTURE IN RATS[J]. Acupuncture research, 1989, (3): 348-351. DOI：

摘要

中枢儿茶酚胺(CA)主要有去甲肾上腺素(NA)和(DA)。我们曾观察到电针后大鼠脑内 NA 和 DA 含量发生显著变化

这种效应与所用的电针频率和强度有密切关系。许多实验研究也支持 NA 和 DA参与针刺镇痛过程。此外

阿片受体拮抗剂纳洛酮广泛被用来间接检查某一生理过程是否有内源性吗啡样物质参与。大量实验表明

无论全身性或脑室注射纳洛酮可以阻断或降低针刺的效应。由于脑内多种神经化学物质在代谢和功能上有着密切的联系。在本工作中

我们观察了大鼠腹腔注射纳洛酮对电针镇痛效应及其脑内 NA 和 DA 含量变化的影响

以便探讨阿片受体在针刺镇痛中对中枢 CA 的调节作用。

Abstract

Rats were randomly divided into 4 groups:Control

Electro-acupuncture(EA)

Naloxone and Naloxone plus EA.The contents of noradrenaline(NA)and dopamine (DA) in brain stem

diencephalon and telencephalon were deter- mined by fluorespectrometry.It was found that the pain threshold increased and the NA content in the telencephalon decreased and the DA level in the brain stem increased markedly after EA.Naloxone injection partially decrea- sed the analgesic effect of EA and abolished the EA-induced elevation of DA in the brain stem and attenuated the NA level in the diencephalon after EA. These results suggest that morphine receptor may play an important role in EA analgesia and this may be patially carried out through the brain cate-cholamine system.

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