我们曾报道

脑室注射促甲状腺素释放激素(TRH)能对抗电针(EA)和吗啡的镇痛效应

其机理不清楚。有资料表明

TRH对抗戊巴比妥的镇痛作用是通过影响神经细胞内cAMP实现的

脑内注入Experiments wese performed on 42 female albino rats weighing from 180-250gm. The pain threshold (PT) was determined by radiant heat induced tailflick method. The cAMP contents in various regions of brain were measured by radio-immunoassay. Electro-aeupuncture (EA) at bilateral "Zusanli" and "Sanyinjian" in rats significantly elevated PT

increased the content of cAMP in the hypophysis

while decreased that of septal nucleus. No effects were found in the basal PT and the cAMP contents of the hypophysis and septal nuclei after intraventricular injection of TRH

After TRH administered intraventricularly

however

EA didn't elevate PT

but still increased hypophysial cAMP with a dereasc in the level of cAMP in the septal nucleus. These results suggest that the cAMP may be related to analgesic effect induced by EA in some brain regions

and TRH injected into cerebral ventricles can antagonize the analgesic effect caused by EA

but this effect seemed to have nn relation to the conents to the contents of cAMP of hypophysis

septal nucleus

caudatum

hypothalamus and thalamus.