近年来的研究资料表明:延髓外侧网状旁巨细胞核(RPGL)是电刺激脑镇痛和吗啡镇痛非常有效的部位。与其它参与吗啡镇痛的脑区(如下丘脑、中脑导水管周围灰质、第四脑室底等)相比

RPGL 对吗啡的敏感性最强。国外对此核团的镇痛机理方面亦做了大量工作

已证明它是痛The present study was aimed to investigate the role of the reticularis pa- ragiganocellularis lateralis (RPGL)in acupuncture analgesia.Tail-flick response to electrical stimulation of the tail skin was taken as index of pain response.The first part of the study consisted of four groups:(1)surgical control

(2)electro-acupuncture

(3)electrical stimulation of RPGL

and (4)stimulation of RPGL simultaneously with electro-acupuncture.The pain thrshold in the first group was quite stable during the experiments

but incre- ased significantly after electro-acupuncture and/or brain stimulation (n=14

P<0.01;n=8

P<0.001;n=14

P<0.001).The pain threshold of the fourth group increased much more than the second and the third group (P<0.001

P<0.01)

In the second part of the study

the effect of electro-acupuncture was reduced significantly after electrical lesion of the RPGL unilaterally (n= 12

P<0.01).The present work indicates that electrical stimulation of RPGL nhances electro-acupuncture analgesia

whereas the lesion of RPGL reduces it.It is suggested that RPGL plays a role in acupuncture analgeia.