近年来国内外文献报道

中枢神经系统的催产素(OT)在痛觉调制过程中发挥着一定的作用

我们最近的工作也表明

脑和脊髓内的OT不仅可以提高大鼠的痛阈

而且能明显增强电针镇痛效应。为进The effect of oxytocin (OT) and cholecystokinin octapeptide (CCK-8) on EA analgesia was studied in rats. The increase of 20.8—39.8% and 9.0—45.0% in pain threshold was observed respectively when ICV of CCK-8 or naloxone was combined with EA

these increases were lower than that in saline-EA group significantly

while the simultaneous ICV of OT and CCK-8 or OT and naloxone in combination with EA produced the increase of 76.2～116.6% and 41.8～104.5% in pain threshold separately. These results showed that only a small part in the role of OT enhancing EA analgesia was blocked by CCK-8 and naloxone. The data suggest that the role of OT in EA was not entirely dependent upon the endogeous opiate peptides.