已有文献报道视前区是脑内与镇痛和针刺镇痛有关的核团之一。我们曾观察到视前区注入6-羟基多巴胺

减少内源性儿茶酚胺含量可以加强针刺镇痛作用

提示视前区内丰富的儿茶酚胺神经递质可能参与针Previous work has shown that activation of catecholamine in the preoptic area is to the disadvantage of acupuncture analgesia. In this work microinjection and push-pull perfusion as well as HPLC-ECD were used to observe the effect of noradrenaline and dopamine in this area on acupuncture analgesia. The results indicated that microinjection of noradrenaline (0.5μg/unilateral) into the preoptic area could attenuate acupuncture analgesia

while dopamine (2μg/unilateral) had no effect on acupuncture analgesia. During acupuncture analgesia

the contents of noradrenaline and MHPG in the perfusate from the preoptic area were markedly decreased

and that of dopamine

however

was not changed significantly. The above results suggest that activating noradrenaline

but not dopamine

exerts antagonistic effect on acupuncture analgesia.