大量资料提示

电针刺激可在中枢神经系统中释放阿片肽而发挥镇痛作用。近年来又发现

不同频率的电针刺激可激活大鼠中枢神经系统不同种类的阿片肽:低频(2Hz)电针促进脑啡肽释放

高频(100Hz)电针促进脊髓中强啡肽的释放。值得注意的是:有一部分大鼠电针不能引起镇痛效果

称为“电针无效鼠”

测定这些大鼠脊Influence of two novel enkephelinase inhibitors

Acetorphan and SCH34826

on the effect of electroacupuncture analgesia (EAA) has been observed in rats. Administered Acetorphan (2.0-4.0mg/kg

i.p.) or SCH34826 (30-100 mg/kg

p.o.) potentiated and prolonged the effect of 2 Hz EAA significantly in the nonresponder in which an evident analgesic effect can not be induced by 2 Hz electroacupuncture. This means that che non-responder of 2 Hz EAA can be converted into the responder with these two drugs. The non-responder of 100 Hz EAA

however

can not be changed into the responder with Acetorphan. These results again support our previous reports that enkephelin plays an important role in low frequency EAA. Meanwhile

this suggests us a probable route for potentiating acupuncture analgesia in clinical practice.