近年来研究资料表明

主要调节血压、内分泌和植物性功能的加压素(Vasopressin

VP)也参与痛觉调制。脑室内注射VP可产生明显的镇痛作用

相反

先天性缺乏In this experment

the role of PVN in acupuncture analgesia was further investigated with electrophysiological technique. In wistar rats the unit discharge was recorded extracellularly

Noxious stimulation was applied to sciatic nerve

and the electroacupuncture was performed on acupoints "Zusanli" and "Sanyinjiao". Totally eighty-two units were recorded successfully from PVN. 49 units of them reacted to electroacupuncture with excitatory (14)

inhiditory (23) or on significant effect (12). Various types of reactions including excitation (12)

inhibition (6)

excito-inhibition (4) or inhibito-excitation (3) were observed on 43 units during noxious stimulation of sciatic nerve. The remainder 18 units had no significant reaction. After electroacupuncture those units reacting with excitatory effect on noxious stimulation decreased their firing rate

and those with inhibitory effect increased their firing rate. The duration of nociccptive reaction was shortened after electroacupuncture in both types of units. It was suggested that electroacupuncture could influence the activities and decrease the nociceptive reactions of PVN neurons

which might be considered as electrophysiological evidence of the involvement of PVN in acupuncture analgesia.