8-精-催产素(8-arginine-vasotocin

AVT)又名管催产素

是松果体分泌的九肽激素

其环状结构部分与催产素(oxytocin

OT)相同

直链部分与精氨酸加压素(Argi-The Asu-AVT(1

6 aminosuberic acid -8-arginine-vasotocin) is an analogue of 8-arginine-vasotocin(AVT) which is one of pineal hormones. The effect of Asu-AVT on the pain threshold and EA analgesia was studied in rats. An increase of 16.2～41.5% in pain threshold was observed within 70 min. after ivc of Asu-AVT(75ng)

while the Asu-AVT injection in combination with EA produced a significant increase of 164.6～309.1% in pain threshold

which was much higher than that in the sahne-EA group(p<0.05～0.01). The effect of Atu-AVT is analogous to that of oxytocin and arginine-vasopressin. The data indicate ivc of ASu-AVT not only elivates the pain threshold

but also enhances the EA analgesia. These results suggest that the pineal hormone

AVT may play a role in the EA analgesia.