Traditional Chinese Medicine holds that meridians is the regulative system of the functional activity of the human body.According to the theory of meri- dians there is a relatively specific connection between the acupoint and viscus. Not a few researchers have paid much attention to this problem.Our previous report showed the mechanical pressure could block the borborygmi caused by puncturing Zusanli(ST 36)in the subjects with marked propagated sensation along meridians(PSM).This paper deals with expriments to compare the influ- ence of pressing the meridian course and non-meridian point on electrogastragram (EGG)during puncturing Zusanli in 33 subjects without PSM.The acupoint Liangqiu(ST 34)was selected as a compressed point and the points on its either side as controls.EGG wes recorded with surface non-polarizable electrode from two abdominal points corresponding to the areas of corpus ventrieuli and antrum pyloricum. The effect of acupuncture on EGG appeared in two kind of rosponses which depended on the amplitude of EGG before acupuncture.The amplitude of EGG increased if it was low before acupuncture.On the contrary

it decreased.The response was bi-directional.It is particular to be noticed that the acupuncture effect was markedly influenced by mechanical pressure.When the pressure was applied on acupoint Liangqiu the acupuncture effect markedly decreased

even disappeared.Whereas mechanical pressure was applied on the both side of Li- angqiu

an influence on acupuncture effect of EGG could not be found.That the acupuncture effect could be blocked by the mechanical pressure applied on the meridian course

regardless of the subjects with or without PSM

was confirmed once again and it may be of universal significance. The results not only suported the viewpoint on“meridian plocking at periphe- ry”but also suggested that there may de an unknown pathway besides the well known neuro-humonal mechanism in realization of the acupuncture effect.