Role of Adenosine in Weak Electro-acupuncture-induced Depression of Nociceptive Response of Spinal Dorsal Horn Neurons in Rats

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Role of Adenosine in Weak Electro-acupuncture-induced Depression of Nociceptive Response of Spinal Dorsal Horn Neurons in Rats

更新时间：2023-08-11

- Role of Adenosine in Weak Electro-acupuncture-induced Depression of Nociceptive Response of Spinal Dorsal Horn Neurons in Rats
- Acupuncture Research Issue 2, Pages: 52-55(1994)
- 作者机构：
  
  中国中医研究院针灸研究所,北京,100700
- 作者简介：
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- Published：1994
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Role of Adenosine in Weak Electro-acupuncture-induced Depression of Nociceptive Response of Spinal Dorsal Horn Neurons in Rats[J]. Acupuncture research, 1994, (2): 52-55.
DOI：

Role of Adenosine in Weak Electro-acupuncture-induced Depression of Nociceptive Response of Spinal Dorsal Horn Neurons in Rats[J]. Acupuncture research, 1994, (2): 52-55. DOI：

摘要

在脊髓横断大鼠，以腰髓背角广动力型（WDR神经元）的伤害性放电为指标，观察弱电针对WDR神经元的抑制作用及静注腺苷受体阻断剂对其的影响。用50Hz，1．0～1．5mA的连续波电针″阳陵泉″-″悬钟″后，WDR神经元的伤害性放电减少，茶碱和咖啡因可阻断电针的抑制效应。提示弱电针可抑制脊髓背角神经无伤害性反应，腺苷可能参与此抑制过程。

Abstract

In this study

extracellular recordings were made from wide dynamic range (WDR) neurons in lumbar segments of the spinal cord in rats transsected at the first lumbar segment. The nociceptive discharges of WDR neurons were depressed by weak electro-acupuncture applied to ″Yanglingquan″-″Xuanzhong″ points. The depression was blocked by i. v. administration of adenosine receptor antagonists

theophylline and caffeine. The observations indicate that depression of the nociceptive response of the WDR neurons induced by weak EA may be mediated by adenosine within the spinal cord.

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