The experimental results demonstrated that moxibustion on Guanyuan point could promote the hyperplasia of the pituitary and the adrenal gland which showed atrophy in control group. Also

the moxibustion treatment stimulated the secretion of β-END from the pituitary and the adrenal gland

increased the level of serum β-END significantly and kept the high level for quite a long time

that was advantageous for β-END to carry out the immunomodulation. The data further suggested that moxibustion treatment do not cause the instant release but probably constant release of the β-END