Influence of SmI Lesion on Acupuncture-Induced Analgesia in Thalamic Pf Neurons and Effects of Iontophoretic Ach on Their Nociceptive Responses

您当前的位置：

首页 >

文章列表页 >

Influence of SmI Lesion on Acupuncture-Induced Analgesia in Thalamic Pf Neurons and Effects of Iontophoretic Ach on Their Nociceptive Responses

更新时间：2023-08-11

- Influence of SmI Lesion on Acupuncture-Induced Analgesia in Thalamic Pf Neurons and Effects of Iontophoretic Ach on Their Nociceptive Responses
- Acupuncture Research Issue 1, Pages: 15-19(1995)
- 作者机构：
  
  中国中医研究院针灸研究所,北京,100700
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1995
- 稿件说明：
移动端阅览
Influence of SmI Lesion on Acupuncture-Induced Analgesia in Thalamic Pf Neurons and Effects of Iontophoretic Ach on Their Nociceptive Responses[J]. Acupuncture research, 1995, (1): 15-19.
DOI：

Influence of SmI Lesion on Acupuncture-Induced Analgesia in Thalamic Pf Neurons and Effects of Iontophoretic Ach on Their Nociceptive Responses[J]. Acupuncture research, 1995, (1): 15-19. DOI：

摘要

用多管微电极细胞外记录及微电泳技术，观察到：毁损大鼠皮层SmI后，电针穴位对丘脑束旁核（Pf）神经无伤害性反应的抑制作用被减弱；微电泳导入ACh能抑制SmI毁损大鼠Pf神经元的伤害性反应，其作用与SmI完整时电针对其伤害性反应的抑制效应相似。结果表明，ACh是参与皮层对丘脑Pf神经元针刺镇痛下行调节的神经递质之一。

Abstract

This study aimed to investigate the role of ACh in SmI emanating descending modulation of thalamic Pf neurons in acupuncture analgesia.Multi-micropipettes were used for both extracellularly recording responses of thalamic Pf neurons to noxious stimulation of the plantar area and drug application in rats.It was found that (1) lesion of SmI obviously attenuated the inhibitory effect of EA applied at "Zusanli"and "Huantiao"points on nociceptive responses in Pfneurons; (2) after lesion of Sml iontophoretic application of ACh markedly suppressed the nociceptive responses of Pf neurons

which was significantly different from the effect of iontophoretic NaCl (as the control) showing no influence on them; (3)the inhibition induced by iontophoretic ACh applied in the rats with lesion of SmI was similar to that produced by EA applied in those with SmI intact.It is indicated that EA can activate SmI to release ACh to exert descending modulation

in which ACh is involved in SmI originating descending regulation of Pf neurons in acupuncture analgesia

关键词

Keywords

references

Views

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Influence of EA and ACh on Nociceptive Responses of Pf Neurons Following Topical Application of HC-3 at SmI in Rats

Iontophoretic Atropine Attenuates the Inhibitory Effect of Stimulating SmI on Nociceptive Responses of pf Neurons

Related Author

徐维

徐志卿

徐维

陈正秋

Chen Zhengqiu Zheng Xin Shi Hong Xu Wei Institute of Acupuncture

China Academy of Traditional Chinese Medicine

Beijing 100700

China)

Related Institution

Institute of Acupuncture, China Academy of Traditional Chinese Medicine

中国中医研究院针灸研究所

Department of Gastroenterology, Tangdu Hospital Affiliated to the Fourth Military Medical University

~1Institute of Neuroscience, the Fourth Military Medical University

Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences

Postal code：100700
Tel：010-64089344,84014607 Email：zcyjbjb@vip.163.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05017590号-8 京公网安备11010802020460号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰