Influence of Neuronal Excitation and Inhibition of Rostral Ventrolateral Medulla on the Effect of Electroacupuncture of“Neiguan”Acupoint

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Influence of Neuronal Excitation and Inhibition of Rostral Ventrolateral Medulla on the Effect of Electroacupuncture of“Neiguan”Acupoint

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- Influence of Neuronal Excitation and Inhibition of Rostral Ventrolateral Medulla on the Effect of Electroacupuncture of“Neiguan”Acupoint
- Acupuncture Research Issue 1, Pages: 34-38(1996)
- 作者机构：
  
  中国中医研究院针灸研究所,北京,100700
- 作者简介：
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- Published：1996
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Influence of Neuronal Excitation and Inhibition of Rostral Ventrolateral Medulla on the Effect of Electroacupuncture of“Neiguan”Acupoint[J]. Acupuncture research, 1996, (1): 34-38.
DOI：

Influence of Neuronal Excitation and Inhibition of Rostral Ventrolateral Medulla on the Effect of Electroacupuncture of“Neiguan”Acupoint[J]. Acupuncture research, 1996, (1): 34-38. DOI：

摘要

在40只乌拉坦和氧醛糖混合麻醉的家免上，观察了注射微量谷氨酸（Glu0．2M，2μl）和甘氨酸（Gly1．3M，2μl）于双侧延胸腹外侧口侧区（rVLM）对结扎冠脉左室支造成心肌缺血后电针“内关”效应的影响。结果表明：（1）电针可明显促进心肌缺血后ECGST段、MBP、LVP及加／dtmax的恢复；（2）Gln可在一定程度上加强电针对MBP、LVP及办／dtmax的作用；（3）Gly可显著削弱电针的作用。这说明当rVLM细胞兴奋时，电针“内关”改善心血管功能的作用似可得到一定程度的加强，而当这些细胞受到抑制时，电针的作用基本消失；rVLM参与电针“内关”对心脏功能的调整过程。

Abstract

Experiments were performed on 44 rabbits anesthetized with a mixture of urethane and chloralose. The effects of microinjection of glutamate and glycine in bilateral rostral ventrolateral medulla (rVLM) on the reaction of electroacupuncture (EA) of "Neiguan" acupoint (PC 6) after myocardial ischemia by ligature of the left ventricular branch of coronary artery were observed. ResuIts showed that (1) EA could significanily promote the recovery of ECG ST-segments

mean blood pressure (MBP)

left ventricular pressure (LVP) and the maximum rising rate of LVP (dp/dt max) ;(2) Glutamate could enhance the effects of EA on MBP

LVP and dp/dt max to a certain extent; (3) The effects of EA could be weakened significantly by glycine. It suggests that EA-induced improvement of the cardiovascular function can be strengthened further in some degree when neurons of rVLM are excited and weakened pronouncedly while the neurons are inhibited. Therefore

rVLM participates in the regulatory process of EA on functional activity of the heart

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