Effect of Electroacupuncture on Cholecystokinin Gene Expression in Rat Hippocampus during Penicillin-induced Epileptic Seizure

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Effect of Electroacupuncture on Cholecystokinin Gene Expression in Rat Hippocampus during Penicillin-induced Epileptic Seizure

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- Effect of Electroacupuncture on Cholecystokinin Gene Expression in Rat Hippocampus during Penicillin-induced Epileptic Seizure
- Acupuncture Research Issue 2, Pages: 62-66(1996)
- 作者机构：
  
  上海医科大学医学神经生物学国家重点实验室,上海,200032
- 作者简介：
- 基金信息：
- DOI：
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- Published：1996
- 稿件说明：
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Effect of Electroacupuncture on Cholecystokinin Gene Expression in Rat Hippocampus during Penicillin-induced Epileptic Seizure[J]. Acupuncture research, 1996, (2): 62-66.
DOI：

Effect of Electroacupuncture on Cholecystokinin Gene Expression in Rat Hippocampus during Penicillin-induced Epileptic Seizure[J]. Acupuncture research, 1996, (2): 62-66. DOI：

摘要

采用原位杂交，NorthernBlot及计算机图像处理技术，观察青霉素致癫痫动物及加电针后海马内胆囊收缩素（CCK）mRNA水平的变化。发现癫痫时，在间脑冠状切面、背海马的齿状回和CA3区，CCKmRNA水平明显提高，电针后，CCKmRNA水平回降，同时在中脑冠状切面、腹海马的下托、背海马的齿状回和CA3区，可见癫痫时CCKmRNA量增加．而电针进一步增加了CCKmRNA的含量。结果提示：电针对青霉素致痫在脑电和行为上表现出来的抑制作用可能与其在海马不同区域调控CCK基因的表达有关。

Abstract

Northern Blot and hybrization in situ techniques were used to investigate the effect of electroacupuncture (EA) on the changes of cholecystokinin (CCK) mRAN levels of the hippocampus in rat penicillin-induced epilepsy model. Epilepsy can significantly increase CCK mRNA levels in dentate gyrus and CA3 areas of hippocampus in diencephalic sections after penicillin-induced seizure

whereas EA not only can attenuate the seizure behaviors and EEG changes

but also can decrease the increase of CCK mRNA contents induced by the seizure. However

in the subiculum

dentate gyrus and CA3 areas of mesencephalic sections of rat hippocampus

EA can further increase the enhancement of CCK mRNA concentration induced by penicillin-induced seizure. The results suggest that EA inhibitory effects on the seizure's behaviors and epileptiform activities may be related to the alteration of CCK gene expression in the different area of hippocampus.

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Related Institution

Cheng Jieshi （National Laboratory of Medical Neurobiology Department of Neurobiology ,Shanghai Medical Universigy ,，）

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1School of Acu-moxibustion,Beijing University of Chinese Medicine

2 Guanganmen Hospital of China Academy of Chinese Medical Sciences

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