Experiments were performed on 53 rats. The nociceptive discharges of spinal dorsal horn neurons were extracellularly recorded by glass microelectrodes and tested for the effects of angiotensin Ⅱ(A Ⅱ ) on the nociceptive discharges of spinal dorsal horn neurons and AII on the inhibitory effects of electroacupuncture (EA ). The results showed as follows: (a) The nociceptive discharges of spinal dorsal horn neurons might be inhibited (25/35) or facilitated (10) with AⅡ (50～ 500ng/20ul) applied to the surface of dorsal spinal cord (L2-3 ); (b)The facilitory effects (5/5 ) were observed with A E (2ug/20ul)applied to the surface of dorsal spinal cord; (c) The inhibitory effects of EA (20Hz

2 - 4V

5min) could be increased with A Ⅱ (250mg/20ul

8/9 ). Therefore

A Ⅱ may modulate the nociceptive response of spinal dorsal horn neurnons and influence the effects of EA

and different effects can be produced when the different dosage of A Ⅱ is applied to the surface of dorsal horn