Influence of Microinjection of Clonidine and Yohimbine in rVLM on the Effect of Electroacupuncture Treatment of Myocardial Ischemia

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Influence of Microinjection of Clonidine and Yohimbine in rVLM on the Effect of Electroacupuncture Treatment of Myocardial Ischemia

更新时间：2023-08-11

- Influence of Microinjection of Clonidine and Yohimbine in rVLM on the Effect of Electroacupuncture Treatment of Myocardial Ischemia
- Acupuncture Research Issue 2, Pages: 31-35(1996)
- 作者机构：
  
  中国中医研究院针灸研究所,北京,100700
- 作者简介：
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- Published：1996
- 稿件说明：
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Influence of Microinjection of Clonidine and Yohimbine in rVLM on the Effect of Electroacupuncture Treatment of Myocardial Ischemia[J]. Acupuncture research, 1996, (2): 31-35.
DOI：

Influence of Microinjection of Clonidine and Yohimbine in rVLM on the Effect of Electroacupuncture Treatment of Myocardial Ischemia[J]. Acupuncture research, 1996, (2): 31-35. DOI：

摘要

在40只氨基甲酸乙脂与氯醛糖混合麻醉的兔上，结扎冠状动脉左心室支造成心肌缺血，观察了注射微量可乐宁（Clon，0．38mMol）及育亨实（Yoh，5．1mMol）各2μl于双侧延脑腹外侧口侧区（rVLM）对电针“内关”效应的影响。结果表明：（1）电针“内关”可明显加快心肌缺血后心电图ST、MBP、LVP及dp/dtmax的恢复；（2）Clon可在一定程度上加强电针对ST及LVP的作用；（3）Yoh可显著削弱电针对ST及LVP的作用。这显示当rVLM内α2受体被兴奋时，电针“内关”对缺血心肌电活动及机械活动的良性调整作用，可得到某种程度的加强；而当α2受体被抑制时，电针的作用基本消失；rVLM细胞α2受体参与电针心包经“内关”对心脏功能的调节过程。

Abstract

In the present paper

influence of tnicroinjection of clonidine (Clon

0. 38 mMol

2μl) and yohirnbine (Yoh

5. 1 mMol

2μl) in rostral ventrolateral medulla (rVLM) on the effect of electroacupuncture (EA) at Neiguan (PC 6) was observed in the rabbit with acute myocardial ischemia. Results showed that (1) EA of Neiguan could significantly accelerate the recovery of AMI-induced changes in ECG ST-segement

mean blood pressure

left ventricular pressure (LVP) and dp/dt rnax; (2) Clon strengthened the effect of EA on ST and LVP in some degree;and (3) Yoh significantly weakened the effect of EA on ST and LVP. lt reveals that when α2 receptors of rVLM are excited

the favourable effect of EA in regulating post-ischemic myocardial electrical and rnechanical activity can be enhanced in some degree; and when they are inhibited

the effect of EA disappears

indicating an involvement of α2 receptors of rVLM in EA of Neiguaninduced regulation on the functional activity of the heart.

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Related Institution

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