Effect of 5-HT and Somatostatin on SP and Chronic Pain Initiated Electrical Activity of Neurons in Spinal Dorsal Horn

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Effect of 5-HT and Somatostatin on SP and Chronic Pain Initiated Electrical Activity of Neurons in Spinal Dorsal Horn

更新时间：2023-08-11

- Effect of 5-HT and Somatostatin on SP and Chronic Pain Initiated Electrical Activity of Neurons in Spinal Dorsal Horn
- Acupuncture Research Issue 3, Pages: 27-31(1996)
- 作者机构：
  
  1. 第三军医大学生理教研室,重庆
  2. ,630038
- 作者简介：
- 基金信息：
- DOI：
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- Published：1996
- 稿件说明：
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Effect of 5-HT and Somatostatin on SP and Chronic Pain Initiated Electrical Activity of Neurons in Spinal Dorsal Horn[J]. Acupuncture research, 1996, (3): 27-31.
DOI：

Effect of 5-HT and Somatostatin on SP and Chronic Pain Initiated Electrical Activity of Neurons in Spinal Dorsal Horn[J]. Acupuncture research, 1996, (3): 27-31. DOI：

摘要

本研究用多管微电极细胞外记录和离子微电泳方法，以Wistar大鼠为实验对象，观察了P物质（SP）对脊髓背角神经元自发放电和慢性伤害性痛放电的影响以及与5-羟色胺（5－HT）和生长抑素（SOM）的关系。结果表明：（1）电泳SP可使脊髓背角神经元单位放电增多。（2）电泳SP又可抑制福尔马林（Formalin）引起的神经元慢性伤害性痛放电。（3）电泳5－HT和SOM可抑制SP及慢痛诱发的脊髓背角神经元放电。上述结果提示：在痛觉调制过程中，脊髓内SP起着传递痛觉信息和镇痛的双重作用，5－HT和SOM可通过抑制SP的效应，参与痛觉调制。

Abstract

The effects of SP on the electric activities of neurons of spinal dorsal horn and the influence of 5-HT

somatostat in (SOM ) on the effects of SP were observed in anesthet ized rats with multimicropipeteand iontophoresis techniques. It was found that. (1 ) The m icroiontop horetically administrating of SPcould increase spinal dorsal horn unit discharge. (2) The noxious electrical activity of neurons inducedby formalin could be inhibited by microiontophoretically applied SP. (3 ) The mi croiontophoretically ad -ministrating of 5-HT and SOM could inhibit the SP and formalin evoked unit discharge of neurons inspinal dorsal horn. It was suggested that SP took a double-effect part in modulation of pain transmissionand analgesia in spinal cord

5-HT and SOM inhibited the effect of SP and participated in pain modula-tion of SP.

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