VIP

SS and PP which exist in gastrointestinal tract and CNS might be to play an important role in nervous system as neurotransmitters of neuromediaters. There have been a few of reports about their changes in plasma and CSF in ICVD. The effects of acupuncture

which was used in treatment of ICVD with good efficiency

on VIP

SS ans PP have not been known. For researching their changes in ICVD and effects of electro-acupuncture on them

and finding the mechanism of acupuncture in treatment of ICVD

the study was performed. The levels of VIP

SS and PP in 64 patients with acute cerebral infarction were deterrnined. The points of acupuncture were Quchi (LI 12 )

Waiguan (SJ 5)

Huantiao (BG 30)

and Zusanli(ST 36). The routine treatment included dextran

nicotinic acid

aspirin

dipyridamole and radix salviae miltiorrnizae composita. The CSF and blood were taken before the begining of treatments and alter a course of treatment. The levels of VIP

SS and PP were meassured by radioimmunoassay.Results showed the level of CSF VIP in the patients was significantly lower as compared with controls.The level of plasma SS in the patients was lower

but the difference was not significant as compared with controls

and level of plasma PP in the patients was significantly increased when it was compared with controls. After electro-acupuncture treatment

in patients with good efficiency

CSF VIP recovered to normal level and the levels of plasma and CSF SS were significantly increased. while the level of plasma PP had no significant change. The results suggest that acupuncture might regulate the disturbances of metabolism of VIP and SS in CNS