Role of Intrahippocampal Kappa Receptor in the Inhibition of Electroconvulsive Seizure by Electroacupuncture(EA) in Rats

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Role of Intrahippocampal Kappa Receptor in the Inhibition of Electroconvulsive Seizure by Electroacupuncture(EA) in Rats

更新时间：2023-08-11

- Role of Intrahippocampal Kappa Receptor in the Inhibition of Electroconvulsive Seizure by Electroacupuncture(EA) in Rats
- Acupuncture Research Issue 2, Pages: 122-125(1998)
- 作者机构：
  
  1. 青岛医学院脑血管病研究所,青岛,266012
  2. 上海医科大学针刺原理研究所神经生物学教研室,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1998
- 稿件说明：
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Role of Intrahippocampal Kappa Receptor in the Inhibition of Electroconvulsive Seizure by Electroacupuncture(EA) in Rats[J]. Acupuncture research, 1998, (2): 122-125.
DOI：

Role of Intrahippocampal Kappa Receptor in the Inhibition of Electroconvulsive Seizure by Electroacupuncture(EA) in Rats[J]. Acupuncture research, 1998, (2): 122-125. DOI：

摘要

大鼠海马内微量注射Kappa受体激动剂U-50488H可以抑制电惊厥的发作，并加强电针对电惊厥的抑制作用，而注射该受体的拮抗剂MR2266或强啡肽A1-13抗血清，均使发作加剧，并可消除电针对电惊厥的抑制作用。结果显示：海马内的Kappa受体及强啡肽与电惊厥发作及电针抑制效应密切相关。

Abstract

The present work mainly deals with the relationship between Kappa receptors of hippocampus and electroacupuncture anticonvulsion. Microinjection of U-50488H into the hippocampus reduced the epileptiform activities and increased the EA anticonvulsion significantly. Microinjection of MR2266 or dynorphin A1

3 antiserum induced the provocation of the epileptiform activities

and resulted in disap pearance or reversal of the inhibitory effects of EA on seizure. The results suggest that Kappareceptors in hippocampus may play an important role in electroconvulsive seizure and EA anticonvulsion

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Related Institution

Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences

1School of Acu-moxibustion,Beijing University of Chinese Medicine

2 Guanganmen Hospital of China Academy of Chinese Medical Sciences

3 Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences

The Affiliated Hospital of Shaanxi College of Chinese Medicine

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