Objective: Observing the therapeutic effect of acupoint injection of self blood mixed with gamma globulin on the morphological changes of the pulmonary and bronchial tissues in allergic asthmatic guinea pigs. Methods: 51 guinea pigs were randomly divided into 1) saline intraperitoneal injection group (n=8)

2) asthma model group (n=8)

3) positive drug group (n=7)

4) self blood acupoint injection group (n=7)

5) gamma globulin acupoint injection group (n=7)

6) self blood plus gamma globulin acupoint injection group

and 7) self blood plus gamma globulin intramuscular injection group (n=7). Bilateral Feishu (BL 13) were used for injection. The injection was conducted once daily with 5 sessions being a therapeutic course

two courses altogether. Results: The results showed that the therapeutic effect of the self blood plus gamma globulin is the best

marked by basic disappearance of the muco embolism

no obvious spasm and no thickening of the smooth muscle

considerable alleviation of the inflammatory cell infiltration and disappearance of the bronchial wall congestion and edema under light microscopic observation. The injection of gamma globulin alone also had the above changes

but the effect was moderate. The effect of the self blood injection is also better

being just a little weaker than that of gamma globulin plus self blood injection. Conclusion: Acupoint injection of self blood mixed with gamma globulin has a fairly good therapeutic effect in improving the structural changes of pulmonary and bronchial tissues in asthmatic guinea pigs.