Research on the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart
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Research on the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart
Acupuncture ResearchIssue 1, Pages: 3-8(2007)
作者机构:
安徽中医学院经脉脏腑相关研究中心
作者简介:
基金信息:
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Published:2007
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ZHOU Yi-ping, WANG Ke-ming, HU Ling, et al. Research on the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart[J]. Acupuncture research, 2007, (1): 3-8.
DOI:
ZHOU Yi-ping, WANG Ke-ming, HU Ling, et al. Research on the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart[J]. Acupuncture research, 2007, (1): 3-8.DOI:
Research on the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart
Objective:To study the scientific basis of specific correlation between the meridian and the Zang-or Fu-organ by using gene differential expression(gene-chip technique)in the rat.Methods:Twenty-one SD rats were randomly and evenly divided into control group
sham-myocardial ischemia(MI)group
MI group
electroacupuncture(EA)-Heart-Meridian(HT)group
EA-Lung-Meridian(LU)group and EA-Small-Intestine-Meridian(SI)group.EA(frequency 2 Hz
stimulating strength 5 V
pulse duration 300 μs)was applied to “Shenmen”(HT 7)-“Tongli”(HT 5)(Heart Meridian)
“Taiyuan”(LU 9)-“Lieque”(LU 7)(Lung Meridian)for 20 min
once daily and continuously for 3 days.Myocardial ischemia model was duplicated by occlusion of the anterior descending branch of the left coronary artery
and myocardial tissue of the left ventricle was taken 3 days after EA treatment for analyzing the differentially expressed genes in different groups with rat whole gene U 230 sequence chips(offered by Affymetrix Company).Results:Compared with model group
among the differentially expressed genes being twofolds and above
the up-regulated and the down-regulated were 20 and 70 in EA-HT group
18 and 26 in EA-SI group
and 14 and 20 in EA-LU group separately.Few same genes with the same differential expression were found among the 3 EA groups.Conclusion:There is exactly a molecular basis in the correlation between Heart Meridian and the heart
and EA of Heart Meridian
Small Intestine Meridian and Lung Meridian have their own special signaling pathways.
Electroacupuncture improves ischemic myocardial injury by activating Nrf2/HO-1 signaling pathway to inhibit ferroptosis in rats
Effect of electroacupuncture preconditioning of “Neiguan”(PC6) on myocardial LKB1/AMPK/PFK2 pathway in myocardial ischemia rats
Effect of Electroacupuncture at “Shenmen”(HT 7)-“Tongli”(HT 5) of Heart Meridian on Neuronal Activities in Paraventricular Nucleus of Hypothalamus in Myocardial Ischemia Rats
Effect of Electroacupuncture Stimulation of Heart and Lung Meridians on Expression of Myocardial HCN 2 in Acute Myocardial Ischemia Rats
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JIANG Zhi-ming
ZHANG Liao
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CAI Rong-lin
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WU Zi-jian
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Related Institution
Anhui Wanbei Coal-electricity Group General Hospital of Rehabilitation
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Institute of Acupuncture-Moxibustion and Meri-dian, Anhui Academy of Traditional Chinese Medicine
Key Laboratory of Xin'an Medicine of the Ministry of Education of the People's Republic of China,Anhui University of Chinese Medicine
The First Affiliated Hospital, Anhui University of Chinese Medicine