Characteristics of Peripheral Afferent Nerve Discharges Evoked by Manual Acupuncture and Electroacupuncture of "Zusanli"(ST 36) in Rats

LI Wei-min1; 2; CHEN Ying-bo2

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Characteristics of Peripheral Afferent Nerve Discharges Evoked by Manual Acupuncture and Electroacupuncture of "Zusanli"(ST 36) in Rats

更新时间：2023-08-11

- Characteristics of Peripheral Afferent Nerve Discharges Evoked by Manual Acupuncture and Electroacupuncture of "Zusanli"(ST 36) in Rats
- Acupuncture Research Issue 1, Pages: 65-70(2008)
- 作者机构：
  
  1. 复旦大学力学与工程科学系
  2. 上海市针灸经络研究中心
  3. 上海市针灸经络研究中心,上海,200433
- 作者简介：
- 基金信息：
- DOI：
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- Published：2008
- 稿件说明：
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LI Wei-min1, 2, CHEN Ying-bo2. Characteristics of Peripheral Afferent Nerve Discharges Evoked by Manual Acupuncture and Electroacupuncture of "Zusanli"(ST 36) in Rats[J]. Acupuncture research, 2008, (1): 65-70.
DOI：

LI Wei-min1, 2, CHEN Ying-bo2. Characteristics of Peripheral Afferent Nerve Discharges Evoked by Manual Acupuncture and Electroacupuncture of "Zusanli"(ST 36) in Rats[J]. Acupuncture research, 2008, (1): 65-70. DOI：

摘要

目的:观察手针、电针刺激大鼠"足三里"穴区时支配该区域的神经束诱发的放电变化

比较不同参数的手针和电针诱发的神经束放电的差异

初步揭示针刺信息的外周传导规律。方法:30只雄性SD大鼠

随机分为手针足三里组和电针足三里组

每组15只。动物用20%乌拉坦麻醉(750 mg/kg)

分离支配右侧"足三里"穴区坐骨神经分支后

分别以不同手法的手针(捻转、提插、捻转提插

1 Hz)及不同参数的电针(5 V、10 V1、5 V

3 Hz)刺激大鼠"足三里"穴各1 min

对刺激过程及刺激前后神经束诱发放电记录采样各1 min

然后进行单位时间神经放电脉冲计数(Bin:1 s)。结果:捻转提插手针"足三里"其神经束放电峰电位数增加最为明显:刺激前的计数为(42.20±1.98)pulses/s;刺激后增为(74.20±18.92)pulses/s(P<0.05);刺激结束后即刻恢复到(41.40±4.85)pulses/s

与刺激后比较P<0.05。单纯提插手针刺激时其神经束放电峰值计数从刺激前的(42.00±3.89)pulses/s增加为(60.60±10.79)pulses/s(P<0.05);针刺结束后即刻恢复至(45.00±18.10)pulses/s

与刺激后比较P<0.05。而单纯捻转手针刺激无明显变化。电针刺激"足三里":强度从5 V左右开始可诱发类似手针诱发的神经放电现象

10 V以上电针其神经放电增加显著

15 V电针接近于单纯提插手法手针所产生的效应:放电峰电位数从刺激前(42.60±3.87)pul-ses/s增加至电针时(64.20±9.36)pulses/s(P<0.05);电针结束后恢复到(48.00±7.55)pulses/s

与电针时比较P<0.05。结论:提插及捻转提插手法的手针刺激大鼠"足三里"可诱发支配该区域的外周神经束放电

且后者放电现象更为明显;一定强度的电针刺激可产生与手针的机械刺激类似的神经放电效应。

Abstract

Objective To observe the nerve discharge changes responding to stimulation of "Zusanli"(ST 36) by manual acupuncture(MA) and electroacupuncture(EA)

so as to reveal the changing regularity of peripheral nerve response.Methods Thirty male SD rats were used in the present study.After anesthetizing with urethane(75 mg/kg) and dissecting a branch of the sciatic nerve innervating ST36 region in the right hind-limb

the ipsilateral ST36 was stimulated with MA(by lifting and thrusting and rotating the acupuncture needle

1 manipulation/s) and EA(5 V

10 V

15 V

and 3 Hz).Discharges of the nerve tract was recorded for 1 min before

during and after MA or EA stimulation respectively

and analyzed in spike counts.Results After lifting

thrusting and rotating the needle

the nerve discharge increased to(74.20±18.92) spikes/s from(42.20±1.98) spikes/s of pre-MA(P<0.05)

then turned to(41.40±4.85) spikes/s immediately after cease of MA.After manual lifting and thrusting the needle

the nerve discharge increased to(60.60±10.79) spikes/s from(42.00±3.89) spikes/s before MA(P<0.05)

and returned to(45.00±18.10) spikes/s immediately after cease of MA.No changes were found after manually rotating the needle(P>0.05).EA at ST36 by increasing the intensity to 5 V began to elicit similar changes of nerve discharges

and increased significantly in a voltage-dependent manner within 5-15 V.EA at the strength of 15 V could produce a marked increase of nerve discharge

being increased to(64.20±9.36) spikes/s from(42.60±3.87) spikes/s before EA(P<0.05)

and then

returned to(48.00±7.55) spikes/s immediately after cease of EA.Conclusion MA of lifting and thrusting

and particularly that of rotating combined with lifting and thrusting at ST36 can significantly potentiate the discharge activity of the sciatic nerve tract

with the response of the latter being more apparent.EA of ST36 at the strength of 10-15 V has a similar effect.It suggests that both mechanical and EA stimulation of ST36 at a certain intensity can produce a similar change of discharges of the afferent nerve innervating ST36 in the rat.

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