Objective To observe the effect of electroacupuncture(EA) on mitochondrial SDH and Na+-K+-ATPase activity

and lactate acid(LA) content in the peri-hemotoma tissue in rats with intracerebral hemorrhage(ICH) so as to explore its mechanisms in resisting cerebral ischemia.Methods A total of 80 Wistar rats were randomized into normal group

sham group

model group

EA group.The last three groups were further divided into 24 h

72 h and 168 h subgroups respectively

with 8 cases in each group/subgroups.ICH model was established by caudatum-injection(right) of Collagense Ⅶ/heparini solution(2 μl).EA(2 Hz

1 mA) was applied to "Baihui"(GV 20)-"Taiyang"(EX-HN 5) for 30 min.Chondriosome suspension of the cerebral peri-hemotoma tissue was got by gradient centrifugation for detecting SDH and Na+-K+-ATPase activity

and LA content with chromometry.Results In comparison with sham-operation group and control group

SDH and mitochondrial Na+-K+-ATPase activity in cerebral peri-hemotoma tissue declined significantly from 72 h and 24 h on respectively(P<0.05)

while LA level increased markedly from 24 h on(P<0.05) in model group.Compared with sham-operation group

SDH activity(168 h) and Na+-K+-ATPase activity(24 h

72 h and 168 h) in EA group also decreased significantly(P<0.05);LA level(24 h

72 h) in EA group increased considerably(P<0.05).Whereas compared with model group

SDH and Na+-K+-ATPase activity increased significantly at most time courses(P<0.05)

and LA level decreased remarkably(P<0.05) in EA group.Conclusion EA can improve the energy metabolism

upregulate the activity of chondriosome

and reduce the accumulation of LA in the cerebral peri-hemotoma tissue of ICH rats.