Effects of Electroacupuncture of "Zusanli" (ST 36),"Hegu" (LI 4) and/or "Sanyinjiao" (SP 9) on Immunofunction in Gastric Carcinectomy Rats
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Effects of Electroacupuncture of "Zusanli" (ST 36),"Hegu" (LI 4) and/or "Sanyinjiao" (SP 9) on Immunofunction in Gastric Carcinectomy Rats
Acupuncture ResearchIssue 4, Pages: 245-249(2008)
作者机构:
1. 重庆医科大学中医药学院
2. 重庆市急救中心
3. 西南大学药学院与中医药学院
作者简介:
基金信息:
DOI:
CLC:
Published:2008
稿件说明:
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LAI Min, WANG Shu-mei, WANG Ying, et al. Effects of Electroacupuncture of "Zusanli" (ST 36),"Hegu" (LI 4) and/or "Sanyinjiao" (SP 9) on Immunofunction in Gastric Carcinectomy Rats[J]. Acupuncture research, 2008, (4): 245-249.
DOI:
LAI Min, WANG Shu-mei, WANG Ying, et al. Effects of Electroacupuncture of "Zusanli" (ST 36),"Hegu" (LI 4) and/or "Sanyinjiao" (SP 9) on Immunofunction in Gastric Carcinectomy Rats[J]. Acupuncture research, 2008, (4): 245-249.DOI:
Effects of Electroacupuncture of "Zusanli" (ST 36),"Hegu" (LI 4) and/or "Sanyinjiao" (SP 9) on Immunofunction in Gastric Carcinectomy Rats
Objective To study the effect of electroacupuncture (EA) of "Zusanli" (ST 36)
"Hegu" (LI 4) and/or "Sanyinjiao" (SP 6) on immune functions in gastric carcinoma rats after operation. Methods Wistar rats were randomly divided into normal control
ST36
LI4
SP6
ST36+LI4
ST36+SP6
LI4+SP6
ST36+LI4+SP6
non-acupoint (about 10 mm lateral to ST36) and model groups
with 6 cases in each. Gastric carcinoma model was made by intraperitoneal injection of Walker-256 cloned strain (0.1 ml
2×107 cells). EA (2-100 Hz
1-3 mA) was applied to these acupoints for 30 min
once daily for 7 days. Serum IgG
IgM
IgA
C3 and C4 contents were detected with simple immunodiffusion method; and CD4+ and CD8+ levels were measured by flow cytometry. Results In comparison with normal control group
serum IgG
IgM
IgA
C3
C4 and CD8+ contents
and CD4+/CD8+ in model group decreased significantly (P<0.05
0.01); while CD8+ content in model group increased remarkably (P<0.01). Compared with model group
serum IgG
IgM
IgA
C3
C4
CD4+
CD8+ and CD4+/CD8+ in non-acupoint group had no significant changes (P>0.05)
while most of these indexes in EA groups (ST36
LI4
SP6
ST36+LI4
ST36+SP6
LI4+SP6
ST36+LI4+SP6) increased considerably (P<0.05
0.01) except CD8+ level (decreased significantly
P<0.05
0.01). No significant differences were found among 7 EA groups (P>0.05)
but the effects of ST36+LI4+SP6 group were slightly better than those of the other 6 EA groups. Conclusion EA of "Zusanli" (ST 36)
"Hegu" (LI 4) or "Sanyinjiao" (SP 6) or two of them or these 3 acupoints can obviously enhance the immune function of post-surgery rats with gastric carcinoma.
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