Effect of Electroacupuncture of Different Acupoints on Blood Pressure,Plasma AngiotensinⅡ,Aldosterone and Atrial Natriuretic Peptide in Spontaneous Hypertension Rats

LIU Wan-ning; JIN Lü-wei; HAN Dong-wei; REN Xiao-xuan; ZHU Jiang; ZHANG Lu-fen

您当前的位置：

首页 >

文章列表页 >

Effect of Electroacupuncture of Different Acupoints on Blood Pressure,Plasma AngiotensinⅡ,Aldosterone and Atrial Natriuretic Peptide in Spontaneous Hypertension Rats

更新时间：2023-08-11

- Effect of Electroacupuncture of Different Acupoints on Blood Pressure,Plasma AngiotensinⅡ,Aldosterone and Atrial Natriuretic Peptide in Spontaneous Hypertension Rats
- Acupuncture Research Vol. 34, Issue 6, Pages: 393-397(2009)
- 作者机构：
  
  北京中医药大学针灸学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2009
- 稿件说明：
移动端阅览
LIU Wan-ning, JIN Lü-wei, HAN Dong-wei, et al. Effect of Electroacupuncture of Different Acupoints on Blood Pressure,Plasma AngiotensinⅡ,Aldosterone and Atrial Natriuretic Peptide in Spontaneous Hypertension Rats[J]. Acupuncture research, 2009, 34(6): 393-397.
DOI：

LIU Wan-ning, JIN Lü-wei, HAN Dong-wei, et al. Effect of Electroacupuncture of Different Acupoints on Blood Pressure,Plasma AngiotensinⅡ,Aldosterone and Atrial Natriuretic Peptide in Spontaneous Hypertension Rats[J]. Acupuncture research, 2009, 34(6): 393-397. DOI：

摘要

目的:通过观察电针不同穴位对自发性高血压大鼠(SHR)血压及血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及心钠素(ANP)的影响

探讨不同穴位对SHR血压影响的规律及可能机制。方法:雄性SHR60只随机分为模型组、曲池组、足三里组、神门组、肩髃组及尾尖组

每组10只。10只同体重Wistar大鼠作为正常组。分别电针"曲池""足三里""神门""肩髃"及尾尖

连续波

频率2Hz

强度2mA

电针30min。使用无创血压测量系统检测针刺前后各组大鼠收缩压和舒张压

放射免疫法检测血浆AngⅡ、ALD及ANP含量。结果:曲池组、足三里组、神门组收缩压及舒张压较针刺前及模型组均明显降低(P<0.05);肩髃组、尾尖组收缩压及舒张压与针刺前及模型组比较

差异均无统计学意义(P>0.05);曲池组和神门组治疗后收缩压低于肩髃组和尾尖组(P<0.05);曲池组、足三里组及神门组舒张压较肩髃组及尾尖组显著降低(P<0.05)。模型组血浆AngⅡ显著低于正常组

血浆ALD水平显著高于正常组(P<0.05);曲池组、足三里组、神门组血浆AngⅡ及足三里组、神门组ALD水平与模型组比较显著下降(P<0.05);神门组血浆AngⅡ及ALD水平低于尾尖组(P<0.05)。模型组血浆ANP水平显著低于正常组(P<0.05);治疗后神门组血浆ANP水平显著高于模型组和肩髃组(P<0.05)。结论:电针"曲池""神门""足三里"可以即刻降低SHR血压

其降压作用可能与对血浆AngⅡ、ALD及ANP的调整作用有关

并有一定的穴位特异性作用。

Abstract

Objective To observe the effect of electroacupuncture(EA)of different acupoints on blood pressure(BP)

plasma angiotensin(Ang)Ⅱ

aldosterone(ALD)and atrial natriuretic peptide(ANP)of SHR

so as to observe the relative specificity of effects of acupoints.Methods A total of 60 SHR were randomly divided into model

Quchi(LI 11)

Zusanli(ST 36)

Shenmen(HT 7)

Jianyu(LI 15)and non-acupoint groups

with 10 cases in each.Other 10 Wistar rats were composed of normal group.EA(2 Hz

2 mA)was applied to LI 11

ST 36

HT 7

LI 15 and non-acupoint for 30 min

followed by measuring BP with BP-6 system.Plasma AngⅡ

ALD and ANP contents were assayed by radioimmunoassay.Results Compared with control group and pre-treatment

both systolic pressure(SP)and diastolic pressure(DP)of Quchi(LI 11)

Zusanli(ST 36)and Shenmen(HT 7)groups lowered significantly(P<0.05).No significant differences were found in the SP and DP of Jianyu(LI 15)and non-acupoint groups(P>0.05).After EA

the SP of Quchi(LI 11)and Shenmen(HT 7)groups were significantly lower than that of Jianyu(LI 15)and non-acupoint groups(P<0.05);and the DP of Quchi(LI 11)

Zusanli(ST 36)and Shenmen(HT 7)groups were markedly lower than that of Jianyu(LI 15)and non-acupoint groups(P<0.05).Compared with normal group

the contents of plasma AngⅡ and ANP of model group decreased significantly

and plasma ALD level of model group increased remarkably(P<0.05).Compared with model group

plasma AngⅡ levels in Quchi(LI 11)

Zusanli(ST 36)and Shenmen(HT 7)groups and ALD in Zusanli(ST 36)and Shenmen(HT 7)groups lowered significantly(P<0.05)

and plasma ANP content in Shenmen(HT 7)group increased obviously(P<0.05).Conclusion EA of LI 11

HT 7 and ST 36 can effectively lowered both DP and SP in SHR

which may be closely related to its effects in regulating the contents of AngⅡ

ALD and ANP.

关键词

Keywords

references

Views

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of electroacupuncture on transforming growth factor-β1 and renal tubular epithelial mesenchymal transformation in renal tissue of spontaneously hypertensive rats

Electroacupuncture of “Jiaji”（EX-B2） improves asthma by reducing airway inflammation and regulating PI3K/AKT/mTOR signaling pathway in rats with allergic asthma

Effect of electroacupuncture on expression in blood-brain barrier in rats with cerebral ischemia-reperfusion injury by regulating HIF-1α/VEGF/MMP-9 signaling pathway

Research progress on the mechanism of acupuncture based on microbiota-gut-brain axis

Related Author

ZHANG Lu-fen

LUO Lei

NING Si-si

YANG Shao-zheng

JIN Jia-hui

WANG Wan-ting

ZHONG Yi-fei

LI Yi

Related Institution

Department of Nephrology, Longhua Hospital Affiliated to Shanghai University of Chinese Medicine

Department of Internal Medicine, Shanghai Changning Tianshan Traditional Chinese Medicine Hospital

Shanghai Huilun Pharmaceutical Co., Ltd.

Nanqiao Town Community Health Service Center,Fengxian District

College of Acupuncture-Moxibustion and Tuina， Chengdu University of Traditional Chinese Medicine

Postal code：100700
Tel：010-64089344,84014607 Email：zcyjbjb@vip.163.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05017590号-8 京公网安备11010802020460号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰