Effects of Transcutaneous Electrical Acupoint Stimulation for Depression in Late Pregnancy and Impacts on Inflammatory Cytokines

CHEN Wei-ye; LI Li; WANG Hui-yuan; JIANG Nan

doi:10.13702/j.1000-0607.160781

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Effects of Transcutaneous Electrical Acupoint Stimulation for Depression in Late Pregnancy and Impacts on Inflammatory Cytokines

更新时间：2023-08-11

- Effects of Transcutaneous Electrical Acupoint Stimulation for Depression in Late Pregnancy and Impacts on Inflammatory Cytokines
- Acupuncture Research Vol. 43, Issue 1, Pages: 43-47(2018)
- 作者机构：
  
  1. 广州市天河区妇幼保健院麻醉科
  2. 广州市天河区妇幼保健院产科
  3. 中山大学附属第一医院麻醉科
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.160781
  CLC：
- Published：2018
- 稿件说明：
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CHEN Wei-ye, LI Li, WANG Hui-yuan, et al. Effects of Transcutaneous Electrical Acupoint Stimulation for Depression in Late Pregnancy and Impacts on Inflammatory Cytokines[J]. Acupuncture research, 2018, 43(1): 43-47.
DOI：

CHEN Wei-ye, LI Li, WANG Hui-yuan, et al. Effects of Transcutaneous Electrical Acupoint Stimulation for Depression in Late Pregnancy and Impacts on Inflammatory Cytokines[J]. Acupuncture research, 2018, 43(1): 43-47. DOI： 10.13702/j.1000-0607.160781.

摘要

目的:评估经皮穴位电刺激(TEAS)治疗孕晚期抑郁的安全性、有效性及对血清炎性细胞因子的影响。方法:孕晚期抑郁妇女随机分为高电流组(n=52)、低电流组(n=49)和对照组(n=49)。各组均取内关、神门穴予TEAS治疗6周

高电流组、低电流组、对照组TEAS治疗电流分别为10、5、0mA。治疗过程中监测胎心率和孕妇宫缩、血压、脉搏。采用24项汉密尔顿抑郁量表(HAMD)评估患者治疗前及治疗2、4、6周的抑郁程度。ELISA法测定治疗前、治疗6周的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和IL-6含量

追踪分娩结局。将治疗前后HAMD变化值分别与TNF-α、IL-1β、IL-6变化值做相关性分析。结果:各组孕妇TEAS治疗前后的血压、脉搏、胎心率差异无统计学意义(P>0.05)。高电流组治疗后各时点HAMD较治疗前降低(P<0.05)

且均低于同时点低电流组和对照组(P<0.05);低电流组治疗6周后HAMD较治疗前降低(P<0.05)

较对照组降低(P<0.05)。高电流组治疗6周后血清IL-1β、IL-6水平均较治疗前降低(P<0.05)

较低电流组和对照组明显降低(P<0.05);3组治疗前后血清TNF-α水平差异均无统计学意义(P>0.05)。各组孕妇分娩结局差异无统计学意义(P>0.05)。治疗前后HAMD变化值与TNF-α、IL-1β、IL-6变化值均不相关(P>0.05)。结论:TEAS可缓解孕晚期抑郁妇女的抑郁程度

降低其血清IL-1β、IL-6浓度

不影响分娩结局

临床应用安全有效。

Abstract

Objective To assess the safety and efficacy of transcutaneous electrical acupoint stimulation(TEAS)for depression in late pregnancy and impacts on inflammatory cytokines.Methods A total of 150 pregnant women with depression in late pregnancy were randomized into a high intensity group(n=52)

a low intensity group(n=49)and a control group(n=49).TEAS was applied at bilateral Neiguan(PC 6)and Shenmen(HT 7)for 6 weeks.The intensities of TEAS in the high intensity group

the low intensity group and the control group were 10

5 and 0 mA

respectively.During the process of TEAS

the blood pressure

pulse

uterine contraction and the fetal heart rate were recorded.Depression was evaluated by 24-item Hamilton depression scale(HAMD)before TEAS and after 2-week

4-week

6-week treatment.Serum levels of tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β)and IL-6 were detected by enzyme-linked immunosorbent assay(ELISA)before and after 6-week treatment.Delivery outcomes were observed.The correlation was analyzed between HAMD difference value and the difference values of TNF-α

IL-1βand IL-6

respectively.Results The blood pressure

pulse and fetal heart rate had no statistical significance before and after treatment in the three groups(P>0.05).The HAMD scores at all the time points were lower than that before treatment in the high intensity group(P<0.05)

which were lower compared with those in the low intensity group and the control group(P<0.05).The HAMD score in the low intensity group decreased after 6-week treatment compared with that before treatment and was lower than that in the control group(P<0.05).The serum levels of IL-1βand IL-6 in the high intensity group decreased compared with those before treatment and were lower compared with those in the low intensity group and the control group after 6-week treatment(P<0.05).There was no significant difference in the deliver outcomes among the three groups(P>0.05).The variation of HAMD score did not have significant correlation with those of TNF-α

IL-1βand IL-6(P>0.05).Conclusion TEAS is safe and effective for depression in late pregnancy and can regulate the serum levels of IL-1βand IL-6 without influencing on delivery outcome.

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