Influence of electroacupuncture of “Zhongwan” (CV12) and “Zusanli” (ST36) in different combinations of stimulating strength and sequence on intragastric pressure in normal rats

CHEN Jian-zhi; LU Meng-jiang; HAN Xu; XU Bin; YU Zhi

doi:10.13702/j.1000-0607.170922

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Influence of electroacupuncture of “Zhongwan” (CV12) and “Zusanli” (ST36) in different combinations of stimulating strength and sequence on intragastric pressure in normal rats

更新时间：2023-08-11

- Influence of electroacupuncture of “Zhongwan” (CV12) and “Zusanli” (ST36) in different combinations of stimulating strength and sequence on intragastric pressure in normal rats
- Acupuncture Research Vol. 44, Issue 2, Pages: 125-130(2019)
- 作者机构：
  
  南京中医药大学针药结合教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.170922
  CLC：
- Published：2019
- 稿件说明：
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CHEN Jian-zhi, LU Meng-jiang, HAN Xu, et al. Influence of electroacupuncture of “Zhongwan” (CV12) and “Zusanli” (ST36) in different combinations of stimulating strength and sequence on intragastric pressure in normal rats[J]. Acupuncture research, 2019, 44(2): 125-130.
DOI：

CHEN Jian-zhi, LU Meng-jiang, HAN Xu, et al. Influence of electroacupuncture of “Zhongwan” (CV12) and “Zusanli” (ST36) in different combinations of stimulating strength and sequence on intragastric pressure in normal rats[J]. Acupuncture research, 2019, 44(2): 125-130. DOI： 10.13702/j.1000-0607.170922.

摘要

目的:观察"中脘""足三里"不同刺激参数组合对正常大鼠胃内压的影响

探索"中脘""足三里"的配伍运用规律。方法:按照进针顺序("中脘"先针/"足三里"先针)和电针刺激强度组合("中脘"1mA和"足三里"1mA、"中脘"1mA和"足三里"2mA、"中脘"1mA和"足三里"4mA)将SD大鼠随机分为6组

每组15只。在动物胃窦放置球囊

连接压力感受器和多导电生理记录系统并记录胃内压

应用2×3×4析因分析方法分析0～30s、30～60s、60～90s、90～120s4个时间段各组电针干预对胃内压的变化倍率值影响

观察电针"中脘""足三里"不同刺激参数组合在不同时间段对大鼠胃内压的影响。结果:在0～30s时间段内

"中脘"对胃内压的效应以抑制为主(P<0.05)

"足三里"穴显示出兴奋的效应趋势(P>0.05)。与0～30s的效应相比

各组电针在30～120s的效应量降低(P<0.01)。在"中脘"1mA和"足三里"1mA刺激下

进针顺序可影响0～30s的效应

对30～120s的效应没有影响;在"中脘"1mA和"足三里"2mA刺激下

进针顺序可影响0～30s和90～120s的效应;在"中脘"1mA和"足三里"4mA刺激下

进针顺序可影响0～120s的效应;"中脘"先针的情况下

"足三里"刺激强度加大到4mA可明显拮抗"中脘"的效应。结论:"中脘"和"足三里"配伍应用可产生拮抗效应

这一效应受进针顺序、电针刺激强度和针刺时间的影响。

Abstract

Objective To observe the effect of electroacupuncture(EA)of"Zhongwan"(CV12)and"Zusanli"(ST36)in different combinations of stimulating parameters on intragastric pressure(IGP)in normal rats so as to explore their best combinations for promoting gastrointestinal mobility.Methods A total of 90 male SD rats were randomly divided into 6 EA groups:CV12-1 mA+ST36-1 mA

CV12-1 mA+ST36-2 mA

CV12-1 mA+ST36-4 mA

ST36-1 mA+CV12-1 mA

ST36-2 mA+CV12-1 mA

and ST36-4 mA+CV12-1 mA which the first acupoint was stimulated first

followed by the second in each group(n=15 rats/group).Before(1 min)

and 0—30 s

30—60 s

60—90 s

and 90—120 sduring EA stimulation of the left ST36 or CV12 first or later

the IGP was measured via an inserted intragastric balloon

a connected pressure transducer and an amplifier.Changes of the IGP were analyzed using 2×3×4 factorial design.Results 1)During 0—30 s

EA-CV12 showed an obvious inhibitory effect on IGP(P<0.05)while EA-ST36 showed a mild exciting effect(P>0.05).2)Compared with the IGP level of 0—30 s

the IGP levels of 30—120 swere significantly decreased in all the groups(P<0.01).3)In the CV12-1 mA/ST 36-1 mA groups

only the IGP level of 0—30 swas affected by the EA-stimulating order(P<0.05).In the CV12-1 mA/ST36-2 mA groups

both the IGP levels during 0—30 sand 90—120 swere obviously affected by EA-stimulating sequence.In the CV12-1 mA/ST36-4 mA groups

the IGP level during 0—120 swas affected by EA-stimulating order.4)Only in the condition of EA-CV12 stimulating first and EAST36 second and at 4 mA

the reduction effect of IGP of EA-CV12 was antagonized.There are marked interaction effects between the EA strength and acupoint EA stimulating sequence

and between the time course and acupoint EA stimulating sequence(P<0.01)

but no significant interaction effects were found between the time course and stimulating strength

and among the EA stimulating strength

time course and acupoint EA stimulating sequence(P>0.05).Conclusion Simultaneous EA stimulation of ST36 and CV12 has an antagonistic effect on IGP in normal rats

which is affected by the stimulating sequence

stimulating strength and time course.

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