Prehypertension is an independent risk factor for end stage of heart

brain and renal diseases.The immune inflammatory imbalance promotes the occurrence of damage of target organs in the pre-hypertension stage.This article focuses on the relationship between the immune-inflammation and prehypertension and its target organ damage.It was found that acupuncture treatment can lower blood pressure

postpone the development of prehypertension

improve vascular endothelia function and immune function

down-regulate the levels of serum proinflammatory cytokines

and reduce inflammatory reactions of the heart and kidney

possible by way of regulating cellular signal pathways as TLR 4/NF-κB

p 38/MAPK

CaM-eNOS-NO

TGF-β1/Smads

etc.and playing aprotective effect on the target organs.However

its detailed mechanisms remain largely unknown up to now.