Characteristics of Spontaneous Discharges of ACG Visceral Nociceptive   Neurons and Non-nociceptive Ones in Cats with Intracellular Recording

doi:10.13702/j.1000-0607.2000.03.004

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Characteristics of Spontaneous Discharges of ACG Visceral Nociceptive Neurons and Non-nociceptive Ones in Cats with Intracellular Recording

更新时间：2023-08-11

- Characteristics of Spontaneous Discharges of ACG Visceral Nociceptive Neurons and Non-nociceptive Ones in Cats with Intracellular Recording
- Acupuncture Research Issue 3, Pages: 179-183(2000)
- 作者机构：
  
  1. 沈阳医学院生理教研室,沈阳,110031
  2. 中国医科大学脑研究所神经生理研究室,沈阳,110001
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2000.03.004
  CLC：
- Published：2000
- 稿件说明：
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Characteristics of Spontaneous Discharges of ACG Visceral Nociceptive Neurons and Non-nociceptive Ones in Cats with Intracellular Recording[J]. Acupuncture research, 2000, (3): 179-183.
DOI：

Characteristics of Spontaneous Discharges of ACG Visceral Nociceptive Neurons and Non-nociceptive Ones in Cats with Intracellular Recording[J]. Acupuncture research, 2000, (3): 179-183. DOI： 10.13702/j.1000-0607.2000.03.004.

摘要

本文应用电刺激内脏大神经作为内脏痛的实验动物模型

通过在体玻璃微电极细胞内电位记录技术

观察了 2 0只猫扣带回前部 1 76个内脏大神经刺激相关神经元的自发放电特性。根据神经元对电刺激内脏大神经产生的诱发反应特性的不同

将其分为内脏伤害感受神经元(84 0 9% )和非伤害感受神经元 (1 5 91 % )。结果表明

有自发放电活动的内脏伤害感受神经元比例数明显高于内脏非伤害感受神经元

前者的静息电位明显低于后者

但是

两者的自发放电形式和频率无明显差异。提示扣带回前部存在内脏伤害感受神经元和内脏非伤害感受神经元

前者的兴奋性高于后者。

Abstract

Electrically stimulating greater splanchnic nerve(GSN) was used as an experiment model of visceral pain.The spontaneous firings of 176 stimulus-relative neurons in anterior cingulate gyrus(ACG)were analyzed by means of the intracellular recording techniques of glass microelectrode in cats.According to characteristics of the evoked response to stimulating GSN

stimulus-relative neurons could be classified into visceral nociceptive neurons(VNNs

8401%)and visceral non-nociceptive neurons(NVNNs

1591%).The main findings were as follows:(1)The percentage of number of spontaneous firing neurons was significantly higher in VNNs than in NVNNs.(2)The resting membrane potential of the former was significantly lower than that of the latter.(3)Modes and frequency of spontaneous discharges of both were not obviously different. The results indicated that there existed VNNs and NVNNs in ACG

and that the excitability of the VNNs was higher than that of the NVNNs.

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Related Institution

~1Institute of Neuroscience, the Fourth Military Medical University

Department of Gastroenterology, Tangdu Hospital Affiliated to the Fourth Military Medical University

华中科技大学同济医学院神经生物学系

Department of Neurobiology,Tongji Medical College,Central-China University of Science and Technology

Institute of Acupuncture and Moxibustion, China Academy of TCM

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