Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway

LI Xiao-xiao; LI Guang-da; MA Yan-yan; CHENG Rong; ZHU Jia-ming; HAN Yong-sheng

doi:10.13702/j.1000-0607.200016

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Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway

更新时间：2023-08-11

- Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway
- Acupuncture Research Vol. 45, Issue 6, Pages: 508-512(2020)
- 作者机构：
  
  1. 安徽中医药大学研究生院
  2. 安徽中医药大学神经病学研究所附属医院
  3. 安徽中医药大学神经病学研究所
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.200016
  CLC：
- Published：2020
- 稿件说明：
移动端阅览
LI Xiao-xiao, LI Guang-da, MA Yan-yan, et al. Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway[J]. Acupuncture research, 2020, 45(6): 508-512.
DOI：

LI Xiao-xiao, LI Guang-da, MA Yan-yan, et al. Advances in the experimental mechanism of acupuncture in the treatment of Alzheimer's disease based on Wnt/β-catenin pathway[J]. Acupuncture research, 2020, 45(6): 508-512. DOI： 10.13702/j.1000-0607.200016.

摘要

研究证实

Wnt/β-catenin信号通路参与了阿尔茨海默病(AD)的发生发展过程。针刺通过对该通路的各靶点及整体的调控实现治疗AD的作用。本文通过对近年来针刺治疗AD的研究进行了回顾和梳理

分别从针刺对Wnt/β-catenin信号通路重要成分(Wnt蛋白、β-catenin、糖原合成酶激酶-3β)及整体、多药耐药性蛋白(ABCB1)、低密度脂蛋白受体相关蛋白-1(LRP-1)等方面的调控作用进行综述。

Abstract

Alzheimer's disease is a neurodegenerative disease closely related to age

which is characterized by cognitive and memory impairment. Extensive studies have confirmed that Wnt/β-catenin signal pathway is involved in the occurrence and development of Alzheimer's disease. With the characteristics of holistic concept and syndrome differentiation

acupuncture is widely used in clinic. Acupuncture plays a role in the treatment of Alzheimer's disease through the regulation of each target and the whole of the pathway. The author reviewed and combed the research on acupuncture treatment of Alzheimer's disease in recent years

and reviewed the regulatory effects of acupuncture on the important components of Wnt/β-catenin signal pathway(Wnt protein

β-catenin

glycogen synthase kinase-3β) and whole

ATP-binding cassette subfamily B member 1(ABCB1)

low density lipoprotein receptor associated protein-1(LRP-1).

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Related Author

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Related Institution

School of Acupuncture Moxibustion and Tuina， Beijing University of Chinese Medicine

Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences

Liaoning Medical College

Hebei Medical University

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