Effects of acupuncture on plasma endogenous opioid peptides in patients with stroke-associated headache in convalescence

LI Shao-kang; LIAO Wei-dong; ZHAO Jie; CAO Xiao-wen

doi:10.13702/j.1000-0607.200150

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Effects of acupuncture on plasma endogenous opioid peptides in patients with stroke-associated headache in convalescence

更新时间：2023-08-10

- Effects of acupuncture on plasma endogenous opioid peptides in patients with stroke-associated headache in convalescence
- Acupuncture Research Vol. 45, Issue 12, Pages: 995-999(2020)
- 作者机构：
  
  1. 上海市浦东新区公利医院针灸科
  2. 深圳市盐田区人民医院集团盐田院区针灸推拿科
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.200150
  CLC：
- Published：2020
- 稿件说明：
移动端阅览
LI Shao-kang, LIAO Wei-dong, ZHAO Jie, et al. Effects of acupuncture on plasma endogenous opioid peptides in patients with stroke-associated headache in convalescence[J]. Acupuncture research, 2020, 45(12): 995-999.
DOI：

LI Shao-kang, LIAO Wei-dong, ZHAO Jie, et al. Effects of acupuncture on plasma endogenous opioid peptides in patients with stroke-associated headache in convalescence[J]. Acupuncture research, 2020, 45(12): 995-999. DOI： 10.13702/j.1000-0607.200150.

摘要

目的:观察针刺治疗缺血性脑卒中恢复期相关性头痛的临床疗效并分析其相关因素。方法:将上海市浦东新区公利医院针灸科2018年10月至2019年12月收治的缺血性脑卒中恢复期相关性头痛患者116例

按照随机数字表法分为治疗组和对照组

每组58例。两组均给予控制血压、血糖、血脂及抗凝等常规治疗。治疗组患者同时给予项七针结合穴位透刺治疗

每次30 min;对照组患者给予盐酸氟桂利嗪胶囊治疗

每次1粒(5 mg);均每日治疗1次

疗程为4周。比较两组患者治疗前后疼痛视觉模拟量尺(VAS)评分

头痛积分

血浆5-羟色胺(5-HT)、多巴胺(DA)、P物质(SP)、α-内啡肽(α-EP)和β-内啡肽(β-EP)含量

并比较两组治疗的总有效率。结果:治疗前两组患者VAS评分

头痛积分

血浆5-HT、DA、SP、α-EP、β-EP含量差异均无统计学意义(P>0.05)。治疗后

两组VAS评分

头痛积分

血浆5-HT、DA、SP含量均低于本组治疗前(P<0.05)

血浆α-EP、β-EP含量高于本组治疗前(P<0.05)。治疗后治疗组VAS评分

头痛积分

血浆5-HT、DA、SP含量低于对照组(P<0.05)

血浆α-EP、β-EP含量高于对照组(P<0.05)。治疗组总有效率为87.9%(51/58)

对照组总有效率为72.4%(42/58)

治疗组临床疗效明显优于对照组(P<0.05)。结论:针刺治疗可通过增加内源性阿片肽释放

降低5-HT、DA、SP等疼痛相关因子分泌

改善卒中相关性头痛症状。

Abstract

Objective To observe the clinical effect of acupuncture on patients with stroke-related headache during convalescent and analyze its related factors. Methods A total of 116 stroke-related headache patients admitted to the Acupuncture Department of Gongli Hospital of Pudong New Area

Shanghai

from October 2018 to December 2019 were divided into a treatment group and a control group according to a random number table

with 58 cases in each group. Patients in both groups were given conventional treatments for control of blood pressure

blood sugar

blood lipids and anticoagulation. At the same time

patients in the treatment group were treated with "nape seven needles"(acupuncture at Fengfu[GV16]

bilateral Fengchi[GB20]

bilateral Tianzhu[BL10] and bilateral Wangu[GB12])combined with penetration needling for 30 min; patients in the control group were treated with Flunarizine hydrochloride capsules(5 mg). Both interventions were conducted once daily for 4 weeks. The visual analogue scale(VAS) score and integrative sores of headache

and plasma serotonin(5-HT)

dopamine(DA)

substance P(SP)

α-endorphin(α-EP)

and β-endorphin(β-EP) levels before and after treatment were compared between the two groups. The total therapeutic effective rate of the two groups was calculated. Results There was no significant difference in VAS score

headache score

plasma 5-HT

α-EP

β-EP levels between the two groups before treatment(P>0.05). After treatment

both groups have significant decrease in the VAS score

integrative sores of headache

the plasma 5-HT

SP levels(P<0.05)

and significant increase in the plasma α-EP and β-EP levels(P<0.05). At the same time

the VAS score

integrative sores of headache

the plasma 5-HT

SP levels of the treatment group were lower(P<0.05)

and the plasma α-EP and β-EP levels were higher(P<0.05) than those in the control group. The total effective rate of the treatment group(51/58

87.9%) was higher than that of the control group(42/58

72.4%

P<0.05).Conclusion Acupuncture therapy can increase the release of endogenous opioid peptide

reduce the secretion of 5-HT

and have a significant effect in treating stroke related headache.

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