Objective To observe the therapeutic effect of "Tiaoyi Sanjiao"(regulating and tonifying the triple energizer)acupuncture and moxibustion in the treatment of cancer-related fatigue of advanced non-small cell lung cancer and observe its influence on lymphocyte count. Methods The cancer-related fatigue patients with advanced non-small cell lung cancer who met the inclusive criteria were randomly divided into 2 groups

with 77 cases in each group. Patients in the control group were treated with conventional Chinese and Western medicine. In the treatment group

on the base of the treatment as the control group

"Tiaoyi Sanjiao" acupuncture and moxibustion was applied(mild moxibustion at Danzhong [CV17]

Zhongwan[CV12]

Qihai[CV6]

bilateral Zusanli[ST36]

and acupuncture at bilateral Xuehai[SP10]

Waiguan[SJ5]

Taichong[LR3]). KPS score

Piper scale

percentage and absolute count of lymphocyte subsets of the two groups before and after treatment were observed. Results Compared with pre-treatment

the KPS scores of both groups were significantly increased after treatment(P

<

0.05); the behavioral dimension score of the Piper scale

and the percentage of B cells of the control group decreased significantly(P

<

0.05); the behavioral dimension

emotional dimension

sensory dimension scores

and total score of the Piper scale in the treatment group were significantly reduced(P

<

0.05)

while the percentage of CD3

+

T cells and absolute counts of CD3+T cells and absolute counts of CD3

+

T cells

CD4+T cells

CD4

+

T cells and CD8+T cells and CD8

+

T cells of the treatment group were significantly increased(P

<

0.05). After treatment

in comparison with the control group

behavioral dimension score of the Piper scale in the treatment group decreased significantly(P

<

0.05); the percentage and absolute counts of B cells and CD4+T cells of the treatment group were significantly increased(P

<

0.05). After treatment

in comparison with the control group

behavioral dimension score of the Piper scale in the treatment group decreased significantly(P

<

0.05); the percentage and absolute counts of B cells and CD4

+

T cells

the absolute count of CD3+T cells

the absolute count of CD3

+

T cells in the treatment group were up-regulated(P

<

0.05). Conclusion "Tiaoyi Sanjiao" acupuncture and moxibustion can significantly alleviate the fatigue state and improve the quality of life in patients with advanced non-small cell lung cancer

which may be achieved by regulating the number of lymphocytes and improving immune function.