Effects of Electroacupuncture of Different Acupoints on Changes of Blood Pressure and Autonomic Nerve System after Colorectal Distension in Rats

CHEN Shu-ping; GAO Yong-hui; YU Xiao-chun1; LIU Jun-ling

doi:10.13702/j.1000-0607.2010.05.003

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Effects of Electroacupuncture of Different Acupoints on Changes of Blood Pressure and Autonomic Nerve System after Colorectal Distension in Rats

更新时间：2023-08-11

- Effects of Electroacupuncture of Different Acupoints on Changes of Blood Pressure and Autonomic Nerve System after Colorectal Distension in Rats
- Acupuncture Research Vol. 35, Issue 5, Pages: 335-341(2010)
- 作者机构：
  
  1. 中国中医科学院针灸研究所
  2. 中国中医科学院医学实验中心
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2010.05.003
  CLC：
- Published：2010
- 稿件说明：
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CHEN Shu-ping, GAO Yong-hui, YU Xiao-chun1, et al. Effects of Electroacupuncture of Different Acupoints on Changes of Blood Pressure and Autonomic Nerve System after Colorectal Distension in Rats[J]. Acupuncture research, 2010, 35(5): 335-341.
DOI：

CHEN Shu-ping, GAO Yong-hui, YU Xiao-chun1, et al. Effects of Electroacupuncture of Different Acupoints on Changes of Blood Pressure and Autonomic Nerve System after Colorectal Distension in Rats[J]. Acupuncture research, 2010, 35(5): 335-341. DOI： 10.13702/j.1000-0607.2010.05.003.

摘要

目的:观察电针对直-结肠扩张(CRD)大鼠血压、心率(HR)及心率变异性(HRV)变化的影响

比较不同穴位对内脏痛、自主神经系统变化调节效应的相对特异性。方法:45只Wistar大鼠

随机分为对照组、足三里组、非穴组、太冲组及内关组

每组9只。麻醉状态下

用肛门内气囊扩张(压力为50

0 mmHg)大鼠直-结肠5 min

电针"足三里""太冲""内关"及非穴区各15 min。电生理记录仪记录颈-胸导联心电图、HR、颈动脉平均压(MAP)及HRV

用频域测定法分析HRV的高频(HF)、低频(LF)成分

并计算其比值。结果:CRD后

大鼠MAP、HR、LF及LF/HF均明显增加(P

0.05)

HF变化不大(P

0.05)。与对照组比较

电针后5、15 min及停针后10 min

足三里组及内关组MAP明显降低(P

0.05)。电针15 min、停针10 min时内关组及停针10 min时足三里组的HR明显低于同组各自CRD期间的值(P

0.05)。电针5 min时足三里及内关组

15 min时足三里、内关、太冲组

停针10 min时足三里组的LF均明显低于对照组(P

0.05)。停针10 min时足三里及内关组的LF/HF明显低于对照组(P

0.05)。各电针组之间的HR、LF及LF/HF值差异均无统计学意义(P

0.05)。结论:电针"足三里""内关"穴可显著降低大鼠CRD后异常升高的MAP、HR及LF/HF

提示电针该两穴区可明显缓解内脏痛

良性调节CRD引起的自主神经功能紊乱

而"太冲"和后肢非穴区作用不明显。

Abstract

Objective To observe the influence of electroacupuncture(EA) of different acupoints on changes of mean arterial pressure(MAP)

heart rate(HR) and heart rate variability(HRV) in colorectal distension(CRD) rats

so as to analyze the specificity of actions of acupoints in relieving visceral pain and regulating activities of the autonomic nerve system.MethodsForty-five Wistar rats were randomized into control

Zusanli(ST 36)

non-acupoint

Neiguan(PC 6) and Taichong(LR 3) groups(n=9/group).Under anesthesia

CRD was given to the rats by using an aerostat for 5 min.EA(2 Hz/15 Hz

2 mA) was applied to bilateral ST 36

non-acupoint(1.0 cm lateral to ST 36)

PC 6 and LR 3 for 15 min

respectively.Electrocardiogram of the cervico-chest lead was recorded by using a bioelectric amplifier

and MAP recorded by using a pressure transducer and an amplifier.Low frequency and high frequency of HRV were analyzed by Chart 5.0.Results Following CRD

the HR

MAP

LF and LF/HF levels increased significantly in all the 5 groups(P<0.05)

while HF had no apparent changes(P>0.05).Compared with the control group

5 min and 15 min after EA

and 10 min after ceasing EA

MAP values of ST 36 and PC 6 groups were decreased obviously(P<0.05).The HR values of ST 36 and PC 6 groups at 15 min after EA and 10 min after ceasing EA were decreased markedly in comparison with those of each of the other groups during CRD(P<0.05).The LF levels of both ST 36 and PC 6 groups at 5 min after EA

and those of ST 36

PC 6 and LR 3 at 15 min after EA were significantly lower than those of control group(P<0.05).LF/HF levels of ST 36 and PC 6 at 10 min after ceasing EA were obviously lower than those of control group(P<0.05).No significant differences were found among ST 36

non-acupoint

PC 6 and LR 3 groups in HR

LF and LF/HF(P>0.05).Conclusion EA of ST 36 and PC 6 can suppress CRD-induced increase of MAP

HR and LF/HF

suggesting beneficial effects of EA in relieving visceral pain and mediating autonomic nerve system.The aforementioned effects of EA of LR 3 and non-acupoint are not obvious.

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