Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension
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Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension
ZHOU Xiao-ling, DU Yan-hua, CHEN Xiao-hui, et al. Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension[J]. Acupuncture research, 2022, 47(2): 165-170.
DOI:
ZHOU Xiao-ling, DU Yan-hua, CHEN Xiao-hui, et al. Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension[J]. Acupuncture research, 2022, 47(2): 165-170. DOI: 10.13702/j.1000-0607.201094.
Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension
治疗8周。比较两组治疗前后中医证候评分、24 h平均收缩压(24 h ASBP)、24 h平均舒张压(24 h ADBP)、24 h平均脉压差(24 h PP)、晨峰血压(MBPS)、24 h SBP变异性(24 h SBPV)、24 h DBP变异性(24 h DBPV)、血清5-羟色胺(5-HT)和褪黑素(MT)含量的变化以及临床疗效。结果:治疗后两组头痛、眩晕、腰酸、膝软、耳鸣评分及24 h ASBP、24 h ADBP、24 h PP、MBPS、24 h SBPV、24 h DBPV均较治疗前降低(P<0.01)
Objective To explore the clinical effect of Pinggan Jiangya decoction combined with penetrating needling at Baihui(GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension(EH). Methods A total of 150 cases of grade 1 and 2 EH patients were randomized into an observation group and a control group
75 cases in each group. In the control group
Pinggan Jiangya decoction was prescribed for oral administration one dose a day
while in the observation group
on the basis of the treatment as the control group
penetrating needling was exerted at GV20 once daily. The treatment duration was 8 weeks. Before and after treatment
the TCM syndrome score
24 h average systolic blood pressure(24 h ASBP)
24 h average diastolic blood pressure(24 h ADBP)
24 h average pulse pressure difference(24 h PP)
morning blood pressure surge(MBPS)
24 h SBP variability(24 h SBPV)
24 h DBP variability(24 h DBPV)
serum levels of 5-hydroxytryptamine(5-HT) and melatonin(MT) were compared in the patients of the two groups. The clinical therapeutic effect was observed in the two groups. Results After the treatment
in the self-comparison of each group
the scores of headache
vertigo
backache
soft knees
tinnitus
24 h ASBP
24 h ADBP
24 h PP
MBPS
24 h SBPV and 24 h DBPV in the two groups were lower than those before treatment(P<0.01)
and the above indexes in the observation group were lower than those in the control group(P<0.01). The level of serum 5-HT after the treatment was lower than that of before the treatment(P<0.01)
while the level of MT was higher than that of before the treatment(P<0.01) in both two groups
and the level of 5-HT in the observation group was lower than that of the control group
while the level of MT was higher than that of the control group(P<0.01). The total effective rate of the observation group was 93.3%(70/75)
better than 76.0%(57/75) of the control group(P<0.01). Conclusion Pinggan Jiangya decoction combined with penetrating needling at GV20 in a period of day from 7 am to 9 am can regulate the levels of serum MT and 5-HT
effectively reduce blood pressure
improve blood pressure variability
control morning peak blood pressure
and has a remarkable effect in the treatment of grade 1 and 2 EH.
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Related Author
LI Shao-yuan
RONG Pei-jing
LI Liang
ZHANG Kai-qi
ZHANG Zi-xuan
XIN Chen
ZHANG Yu-zheng-heng
CHEN Bin
Related Institution
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Wangjing Hospital, China Academy of Chinese Medical Sciences
Neurology Department,The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine
Rehabilitation Department,The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine
Research Department,The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine