Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure

MA Shu-hua1; GAO Jun-hong2; WANG Yu-min1; ZHANG Meng3; MA Yan-yan1; HU Jian-jiang1; FU Wei-xing2; CUI Hai-feng1; YU Xiao-chun1

doi:10.13702/j.1000-0607.2011.03.014

您当前的位置：

首页 >

文章列表页 >

Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure

更新时间：2023-08-11

- Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure
- Acupuncture Research Vol. 36, Issue 3, Pages: 225-229(2011)
- 作者机构：
  
  1. 中国中医科学院医学实验中心
  2. 中国中医科学院针灸研究所
  3. 辽宁医学院药理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2011.03.014
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
MA Shu-hua1, GAO Jun-hong2, WANG Yu-min1, et al. Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure[J]. Acupuncture research, 2011, 36(3): 225-229.
DOI：

MA Shu-hua1, GAO Jun-hong2, WANG Yu-min1, et al. Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure[J]. Acupuncture research, 2011, 36(3): 225-229. DOI： 10.13702/j.1000-0607.2011.03.014.

摘要

洋地黄作为广泛使用的治疗心衰的强心药

极易引起心律失常等毒副作用。寻找促使洋地黄增效减毒的方法对提高洋地黄的疗效和安全性意义重大。研究表明

针灸可改善缺血性心脏功能损害

抑制缺血性心律失常

针灸与化疗药物联用亦可减少其毒副作用

提示针灸与洋地黄联用可能起到增效减毒的作用。针刺有可能通过调节众多与心肌细胞内钙调节相关的分子、结构或功能

抑制心衰的发展;通过改善心肌细胞肌浆网钙泵功能、提高心肌肌钙蛋白对Ca2+的敏感性

来增强心肌收缩功能

并降低洋地黄非毒性的起效浓度

从而起到对洋地黄的增效减毒作用。上述思路为针药结合治疗心衰提供了新的线索。

Abstract

Digitalis glycosides

a group of cardiotonic agents for heart failure

have been used for a long time

but may often trigger arrhythmias as a result of digitalis intoxication.It is of great significance in finding a method to reduce their toxicity and improve clinical curative effects simultaneously in the application of digitalis glycosides.It has been well documented that acupuncture has good therapeutic effects in improving cardiac function and inhibiting arrhythmia induced by myocardial ischemia.Acupuncture combined with chemotherapeutics can reduce the adverse effects of chemotherapeutics.Accordingly

acupuncture combined with digitalis is likely to reduce the side effects of digitalis by regulating intracellular Ca2+

improving the function of Ca2+-ATPase in the sarcoplasmic reticulum

increasing calcium sensitivity of cardiac troponin

etc.These considerations may provide a novel clue for treatment of heart failure by joint administration of acupuncture and drugs.

关键词

Keywords

references

Views

635

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Electroacupuncture improves long-term survival of myocardial infarction mice by promoting myocardial angiogenesis and inhibiting ventricular remodeling

Observation on facilitation and attenuation effect of electroacupuncture combined with aconitine for treatment of heart failure in rats

Related Author

ZHANG Jiao-jiao

XIE Chen-long

YONG Yue

CHI Hao

LU Li-yue

ZOU Ying-hua

RUAN Wen-qing

SONG Jian-gang

Related Institution

Clinical Medical College of Shuguang, Shanghai University of Traditional Chinese Medicine

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences

Postal code：100700
Tel：010-64089344,84014607 Email：zcyjbjb@vip.163.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05017590号-8 京公网安备11010802020460号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰