Effect of Electroacupuncture at Different Frequencies on Serum Estradiol and Progesterone Levels in Late-stage Pregnancy Rats

ZHU Ling1; 2; YANG Fang3; JIN Chun-lan4; MA Liang-xiao1; CHEN Ying-ru4; YUAN Hong-wen1

doi:10.13702/j.1000-0607.2012.04.006

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Effect of Electroacupuncture at Different Frequencies on Serum Estradiol and Progesterone Levels in Late-stage Pregnancy Rats

更新时间：2023-08-11

- Effect of Electroacupuncture at Different Frequencies on Serum Estradiol and Progesterone Levels in Late-stage Pregnancy Rats
- Acupuncture Research Vol. 37, Issue 4, Pages: 281-285(2012)
- 作者机构：
  
  1. 北京中医药大学针灸推拿学院
  2. 煤炭总医院中医科
  3. 辽宁中医药大学
  4. 中国中医科学院针灸研究所
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2012.04.006
  CLC：
- Published：2012
- 稿件说明：
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ZHU Ling1, 2, YANG Fang3, et al. Effect of Electroacupuncture at Different Frequencies on Serum Estradiol and Progesterone Levels in Late-stage Pregnancy Rats[J]. Acupuncture research, 2012, 37(4): 281-285.
DOI：

ZHU Ling1, 2, YANG Fang3, et al. Effect of Electroacupuncture at Different Frequencies on Serum Estradiol and Progesterone Levels in Late-stage Pregnancy Rats[J]. Acupuncture research, 2012, 37(4): 281-285. DOI： 10.13702/j.1000-0607.2012.04.006.

摘要

目的:观察不同频率电针对晚孕大鼠血清雌二醇(E2)及孕酮(P)含量、血栓素B2(TXB2)及6-酮-前列腺素(6-keto-PGF1α)含量以及其比值的影响

探讨不同频率电针促晚孕大鼠分娩的机制。方法:健康成年晚孕Wistar大鼠66只

随机分正常组、模型组和4个不同频率电针组(2Hz、20Hz、50Hz、100Hz)。除正常组外均用托盘法造成大鼠妊娠模型。4个电针组于受孕第19日上午进行电针干预

取双侧"合谷""三阴交"穴

先电针"合谷"穴20min

再针"三阴交"5min

共留针25min。用放射免疫法测定血清E2、P、TXB2、6-keto-PGF1α含量

并计算E2/P、TXB2/6-keto-PGF1α比值。结果:与模型组比较

2Hz、20Hz电针组血清E2含量显著升高(P<0.05)。各电针组血清P含量比较

100Hz较20Hz和50Hz组显著增高(P<0.05)。与模型组比较

2 Hz、50 Hz电针组血清TXB2含量显著升高(P<0.01

P<0.05)。结论:2Hz、50Hz频率电针可升高血清TXB2含量及E2/P比值

提示2Hz和50Hz电针更有利于触发宫缩

加快产程。

Abstract

Objective To observe the effect of electroacupuncture(EA) at different frequencies on serum estradiol(E2)

progesterone(P)

thromboxance B2(TXB2)

6-Keton-prostaglandin F 1 alpha(6-keto-PGF1α)contents in late pregnancy rats so as to study its mechanisms underlying labor promotion.Methods A total of 66 late-stage pregnant Wistar rats were randomly divided into 6 groups: normal control

late-pregnancy model(model)

2 Hz-EA

20 Hz-EA

50 Hz-EA and 100 Hz-EA groups

with 11 rats in each group.On the 19th day after pregnancy

EA(2 Hz

20 Hz

50 Hz

100 Hz

0.1 mA) was applied to bilateral "Hegu"(LI 4) for 20 min first and to bilateral "Sanyinjiao"(SP 6) for 5 min afterwards.Serum E2

TXB2 and 6-keto-PGF1α contents were assayed by radioimmunoassay

and the ratios of E2/P and TXB2/6-keto-PGF1αwere calculated.Results Compared to the normal control group

serum E2 contents in 2 Hz-EA

20 Hz-EA

50 Hz-EA and 100 Hz-EA groups were increased significantly(P<0.001

P<0.01

P<0.05).Compared to the model group

serum E2 levels in the 2 Hz-EA and 20 Hz-EA groups were up-regulated further significantly(P<0.05).Comparison among the four EA groups showed that serum P level in the 100 Hz-EA group was significantly higher than those in the 20 Hz-EA and 50 Hz-EA groups(P<0.05).Compared to the normal control group

the contents of serum TXB2 and the ratios of E2/P in both 2 Hz-EA and 50 Hz-EA groups were significantly higher(P<0.05

P<0.001

P<0.01).Conclusion Both 2 Hz and 20 Hz EA can effectively increase serum E2.content

and 2 Hz and 50 Hz EA can raise serum TXB2 and E2/P levels in late pregnancy rats

which may contribute to their effects in strengthening the uterine contractility to promote labor by regulating hormone secretion.

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