Effect of Different Intensities of Electroacupuncture Stimulation on Expression of SOCS-3 and PPAR-γ mRNA in Adipose Tissues of Obesity Rats

GAO Jie; TANG Cheng-lin; LIU Ren-jian; CHEN Xiao-lin; XIE Hui; HOU Yi-xuan; YU Min; LIU Zu-li

doi:10.13702/j.1000-0607.2013.01.006

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Effect of Different Intensities of Electroacupuncture Stimulation on Expression of SOCS-3 and PPAR-γ mRNA in Adipose Tissues of Obesity Rats

更新时间：2023-08-11

- Effect of Different Intensities of Electroacupuncture Stimulation on Expression of SOCS-3 and PPAR-γ mRNA in Adipose Tissues of Obesity Rats
- Acupuncture Research Vol. 38, Issue 1, Pages: 31-34(2013)
- 作者机构：
  
  重庆医科大学中医药学院
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2013.01.006
  CLC：
- Published：2013
- 稿件说明：
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GAO Jie, TANG Cheng-lin, LIU Ren-jian, et al. Effect of Different Intensities of Electroacupuncture Stimulation on Expression of SOCS-3 and PPAR-γ mRNA in Adipose Tissues of Obesity Rats[J]. Acupuncture research, 2013, 38(1): 31-34.
DOI：

GAO Jie, TANG Cheng-lin, LIU Ren-jian, et al. Effect of Different Intensities of Electroacupuncture Stimulation on Expression of SOCS-3 and PPAR-γ mRNA in Adipose Tissues of Obesity Rats[J]. Acupuncture research, 2013, 38(1): 31-34. DOI： 10.13702/j.1000-0607.2013.01.006.

摘要

目的:观察不同电针强度对单纯性肥胖大鼠脂肪组织中细胞因子信号转导抑制蛋白-3(SOCS-3)

以及过氧化物酶体增殖物激活受体-γ(PPAR-γ)mRNA表达的影响

探讨电针对细胞信号传导通路的调控机制。方法:SD大鼠随机分为普食组、模型组、5mA电针组、1mA电针组

每组10只

喂食高脂饲料造肥胖大鼠模型。电针组针刺双侧"足三里""三阴交"

每天治疗1次

每次15min

共治疗2周。观察大鼠治疗前后体质量变化情况

反转录-聚合酶链反应法检测大鼠附睾脂肪组织SOCS-3及PPAR-γmRNA的表达。结果:造模后

各组大鼠体质量及SOCS-3、PPAR-γmRNA表达较普食组均明显升高(P<0.01);治疗后

两电针组体质量及SOCS-3、PPAR-γmRNA表达较模型组均降低(P<0.01)

5mA电针较1mA电针效果更明显(P<0.01)。结论:电针"足三里""三阴交"穴对单纯性肥胖大鼠体质量及SOCS-3、PPAR-γ过度表达有良性调节作用

5mA电针比1mA电针效果更好。

Abstract

Objective To observe the effect of electroacupuncture(EA) on the expression of suppressor of cytokine signaling 3(SOCS-3) and peroxisome proliferator-activated receptor(PPAR)-γ genes in the epididymis adipose tissue of obesity rats so as to explore its mechanism underlying weight reduction.Methods SD rats were randomized into normal control

obesity model

EA-5 mA and EA-1 mA groups(10 rats/group).EA stimulation(6 Hz/20 Hz

5 mA or 1 mA) was delivered to the bi-lateral "Zusanli"(ST 36) and "Sanyinjiao"(SP 6) for 15 min

once everyday for two weeks.The expression of SOCS-3 mRNA and PPAR-γ mRNA in the epididymis adipose tissue was detected by reverse transcriptase polymerase chain reaction.Results Compared with the normal group

the body weight and expression of SOCS-3 and PPAR-γ mRNA in the model group were up-re-gulated obviously(P<0.01).Compared with the model group

the body weight and expression of SOCS-3 and PPAR-γ mRNA were significantly decreased in the EA group

with the effects of EA-5 mA being better than those of EA-1 mA.Conclusion EA stimulation of ST 36-SP 6 can reduce body weight in rats with simple obesity

and the effect of higher intensity of EA is apparently better.Accordingly

EA intervention induces down-regulation of SOCS-3 and PPAR-γ mRNA expression in the epididymis adipose tissue.

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YU Min1

XIAO Xiao-qiu2

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Related Institution

Department of Acupuncture-moxibustion, Hubei Provincial Hospital of Traditional Chinese Medicine

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Kaifeng Hospital of Traditional Chinese Medicine

1 College of Chinese Medicine,2Institute of Life Sciences,3 Section of Scientific Research,Chongqing Medical University

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