A Feasibility Analysis on Individualized Acupuncture Treatment of Irritable Bowel Syndrome under Help of Genetic Polymorphism Technique

WU Xiao-liang; SUN Jian-hua; LIU Lan-ying; FU Hai-yang; JIAO Dai-yan; SHU Yan-ye; CHEN Dong; LIU Cheng-yong; ZHAN Dao-wei; ZHANG Wei

doi:10.13702/j.1000-0607.2014.03.015

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A Feasibility Analysis on Individualized Acupuncture Treatment of Irritable Bowel Syndrome under Help of Genetic Polymorphism Technique

更新时间：2023-08-11

- A Feasibility Analysis on Individualized Acupuncture Treatment of Irritable Bowel Syndrome under Help of Genetic Polymorphism Technique
- Acupuncture Research Vol. 39, Issue 3, Pages: 252-255(2014)
- 作者机构：
  
  1. 南京中医药大学附属医院针灸康复科
  2. 南京中医药大学第二临床医学院
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2014.03.015
  CLC：
- Published：2014
- 稿件说明：
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WU Xiao-liang, SUN Jian-hua, LIU Lan-ying, et al. A Feasibility Analysis on Individualized Acupuncture Treatment of Irritable Bowel Syndrome under Help of Genetic Polymorphism Technique[J]. Acupuncture research, 2014, 39(3): 252-255.
DOI：

WU Xiao-liang, SUN Jian-hua, LIU Lan-ying, et al. A Feasibility Analysis on Individualized Acupuncture Treatment of Irritable Bowel Syndrome under Help of Genetic Polymorphism Technique[J]. Acupuncture research, 2014, 39(3): 252-255. DOI： 10.13702/j.1000-0607.2014.03.015.

摘要

随着基因多态性技术在疾病个体化治疗中的应用

5-羟色胺(5-HT)转运体基因多态性标志物的筛选是目前肠易激综合征的研究热点

通过分析目前肠易激综合征的针刺和中药结合诊疗规范化方案以及5-HT转运体基因多态性及针刺在该方向的研究成果

在目前形成的肠易激综合征针药结合规范化诊疗方案基础上

评估和筛选5-HT转运体基因多态性标志物在肠易激综合征针刺个体化治疗中的重要性和指导意义

为进一步个体化治疗指导方案的建立提供依据。

Abstract

Along with the application of genetic polymorphism techniques to individualized treatment of clinical disorders

the screening of polymorphisms markers of serotonin(5-HT)transporter(SERT)is a hot-spot of researches on irritable bowel syndrome(IBS).In the present paper

the authors introduce 1)optimized schemes of diagnosis and treatment of IBS on the basis of syndrome-differentiation for acupuncture in combination with Chinese herbal medicines

and application of 5-HT transporter polymorphism

2)application of genetic polymorphism to researches on IBS

and 3)feasibility of genetic polymorphism techniques for guiding individualized treatment of IBS.Up to now

serotonin transporter length polymorphic region(5-HTTLPR)

serotonin transporter intron 2variable number of tandem repeat(Stin 2VNTR)and single nucleotide polymorphism rs 25531in the long allele of the 5-HTTLPR have been identified.On the basis of the treatment of IBS

we need establishing a set of guide lines for the individualized acupuncture treatment.The genotyping methods for genetic polymorphism should be widely used in this research field.5-HT TLPR/Stin 2VNTR/rs 25531polymorphisms would have a bright future in the field of IBS research and treatment.

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