Objective To observe the effect of electroacupuncture(EA)stimulation of"Neiguan"(PC 6)and"Sanyinjiao"(SP 6)on morphological changes

myocardial energy metabolism in rats undergoing simulated weightlessness.MethodsA total of 40 male Wistar rats were randomly divided into normal control

weightlessness model

Neiguan(PC 6)and Sanyinjiao(SP 6)groups(10rats/group).EA was applied to PC 6and SP 6acupoints for 30 min

once every other day.The morphological changes were observed by light microscopy after H.E.staining.Lactate dehydrogenase(LDH)

succinate dehydrogenase(SDH)and ATPase activities in the left ventricular myocardium were measured by colorimetry.Results In weightlessness rats

myocardial pathological changes as loose arrangement

breakage and lytic necrosis of myocardial fibers were found

these changes were obviously improved in rats of both PC 6and SP 6groups.Compared with the control group

the ATPase activity was significantly decreased

while the LDH activity was significantly increased in the model group(P<0.05).After EA intervention

the ATPase activity was obviously increased in the SP 6group(P<0.05)

and LDH activity was apparently reduced in both PC 6and SP 6groups(P<0.05).No significant changes were found in myocardial SDH activity after modeling and EA of the two acupoints(P>0.05).Conclusion EA intervention has functions in up-regulating ATP activity and suppressing the myocardial LDH activity in weightlessness rats

which may be related to its effect in improving myocardial pathological changes.