Objective To observe the effect of preconditioning of catgut implantation on changes of behavior and EEG of rats with epilepsy.Methods Forty male Wistar rats were randomly divided into control

model

catgut implantation

medication groups(10rats/group).The catgut implantation was performed at"Yintang"(EX 2)to"Baihui"(GV 20)and"Changqiang"(GV 1)on day 1

4and 7.The epileptic model was made by intraperitoneal injection of penicillin sodium on the last day of the treatment.In the medication group

intragastric administration of valproic acid sodium was conducted once a day for consecutive 7days.Behavior measurement and EEG recording were carried out shortly after the penicillin administration.Results Compared with the model group

the seizure latency was notably increased in the catgut implantation group and the medication group(P<0.01)

without significant difference between the last two groups(P>0.05).The degree of the seizure attack was less severe in the catgut implantation group and the medication group(P<0.01)

without significant difference between the two groups(P>0.05).Similar to valproic acid sodium

catgut implantation significantly reduced the amplitude and accelerated the frequency of EEG(P<0.01).Conclusion Catgut implantation can delay the seizure attack latency

alleviate the severity

regulate the amplitude and frequency of the epileptiform discharges

giving rise to evident antiepileptic effect.