Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acupuncture Therapy for Rheumatoid Arthritis

HONG Shou-hai; DING Sha-sha; ZHANG Kuo; XU Yuan; ZHAO Xue; XUAN Li-hua; GUO Yi

doi:10.13702/j.1000-0607.2016.05.020

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Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acupuncture Therapy for Rheumatoid Arthritis

更新时间：2023-08-11

- Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acupuncture Therapy for Rheumatoid Arthritis
- Acupuncture Research Vol. 41, Issue 5, Pages: 469-473(2016)
- 作者机构：
  
  1. 浙江省中医院针灸科
  2. 天津中医药大学实验针灸学研究中心
  3. 天津市南开医院针灸科
- 作者简介：
- 基金信息：
- DOI：10.13702/j.1000-0607.2016.05.020
  CLC：
- Published：2016
- 稿件说明：
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HONG Shou-hai, DING Sha-sha, ZHANG Kuo, et al. Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acupuncture Therapy for Rheumatoid Arthritis[J]. Acupuncture research, 2016, 41(5): 469-473.
DOI：

HONG Shou-hai, DING Sha-sha, ZHANG Kuo, et al. Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acupuncture Therapy for Rheumatoid Arthritis[J]. Acupuncture research, 2016, 41(5): 469-473. DOI： 10.13702/j.1000-0607.2016.05.020.

摘要

细胞因子与类风湿关节炎(RA)的发生、发展密切相关。针刺可通过提高抗炎细胞因子含量、降低促炎细胞因子含量

调整Th 1/Th 2平衡

从而达到抗炎、镇痛的作用

充分体现了针刺双向调节的作用特点。目前的研究也存在一些问题

如相关细胞因子研究的深度、广度和新度不够;研究水平不高

各研究结果之间存在一定矛盾;研究缺乏中医整体观等。因此

结合目前细胞因子与RA、神经-内分泌-免疫网络作用机制的最新研究进展

采用目前高通量的细胞因子检测手段

将针刺治疗后机体多靶点部位(关节局部、外周血液、中枢)的细胞因子相结合

整体、动态、网络地研究针刺对RA细胞因子的影响

有望取得新进展。

Abstract

Cytokines are closely related to the occurrence and development of rheumatoid arthritis(RA).Acupuncture exerts anti-inflammatory and analgesic effects via elevating anti-inflammatory cytokine level and reducing pro-inflammatory cytokine level and regulating Th 1/Th 2balance

which reflects the dual directional regulatory effect of acupuncture.However

problems exist in the current researches

such as inadequate depth

limited breadth and not so up-to-date research focus.The mediocre research level and the phenomena of some contradictory results among studies also need being concerned.Therefore

progress may be attained if a holistic

dynamic and networked study is conducted on the influence of acupuncture on cytokines by combining the latest progress in the mechanisms of network of cytokines and neuroendocrine immune network

and high throughput cytokine capture assay.In this way

the mechanism of cytokines in multi-targets(such as local joints

peripheral blood circulation

central nervous system)involving the effects of acupuncture in improving RA will be known more.

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Key Laboratory of Acupuncture and Medicine Research of Ministry of Education， Nanjing University of Chinese Medicine

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